GO Annotations Graph

• Symbol: Hyal2
• Name: hyaluronoglucosaminidase 2
• ID: MGI:1196334

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	IPI	J:150686
Molecular Function	GO:0005540	hyaluronic acid binding	ISS	J:148918
Molecular Function	GO:0005540	hyaluronic acid binding	ISO	J:164563
Molecular Function	GO:0033906	hyaluronoglucuronidase activity	ISO	J:164563
Molecular Function	GO:0033906	hyaluronoglucuronidase activity	ISO	J:155856
Molecular Function	GO:0033906	hyaluronoglucuronidase activity	IBA	J:265628
Molecular Function	GO:0004415	hyalurononglucosaminidase activity	ISS	J:148918
Molecular Function	GO:0004415	hyalurononglucosaminidase activity	ISO	J:323605
Molecular Function	GO:0004415	hyalurononglucosaminidase activity	IMP	J:239258
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	J:60000
Molecular Function	GO:0030294	receptor signaling protein tyrosine kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	IDA	J:150686
Molecular Function	GO:0050431	transforming growth factor beta binding	IPI	J:150686
Molecular Function	GO:0001618	virus receptor activity	IDA	J:182416
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:150686
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:148918
Cellular Component	GO:0000139	Golgi membrane	ISS	J:183194
Cellular Component	GO:0000139	Golgi membrane	ISO	J:155856
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	IDA	J:183194
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:183194
Cellular Component	GO:0045121	membrane raft	ISO	J:323605
Cellular Component	GO:0005902	microvillus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:183194
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IDA	J:150686
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:72247
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	ISO	J:164563
Biological Process	GO:0071347	cellular response to interleukin-1	ISO	J:164563
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	IDA	J:150686
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:164563
Biological Process	GO:0071493	cellular response to UV-B	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	IDA	J:182393
Biological Process	GO:0019064	fusion of virus membrane with host plasma membrane	ISO	J:164563
Biological Process	GO:0006027	glycosaminoglycan catabolic process	ISO	J:164563
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	IMP	J:146040
Biological Process	GO:0030214	hyaluronan catabolic process	ISO	J:164563
Biological Process	GO:0030214	hyaluronan catabolic process	ISS	J:148918
Biological Process	GO:0030214	hyaluronan catabolic process	ISO	J:155856
Biological Process	GO:0030214	hyaluronan catabolic process	IBA	J:265628
Biological Process	GO:0030214	hyaluronan catabolic process	IMP	J:193882
Biological Process	GO:0030214	hyaluronan catabolic process	IMP	J:239258
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0042117	monocyte activation	ISS	J:148918
Biological Process	GO:0042117	monocyte activation	ISO	J:164563
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:146040
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0010764	negative regulation of fibroblast migration	ISO	J:164563
Biological Process	GO:0043407	negative regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0061099	negative regulation of protein tyrosine kinase activity	ISO	J:164563
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IMP	J:150686
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IDA	J:150686
Biological Process	GO:0050729	positive regulation of inflammatory response	ISS	J:148918
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISS	J:148918
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISS	J:148918
Biological Process	GO:0042307	positive regulation of protein import into nucleus	IDA	J:150686
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:150686
Biological Process	GO:0000302	response to reactive oxygen species	ISO	J:164563
Biological Process	GO:0009615	response to virus	IDA	J:182416
Biological Process	GO:0009615	response to virus	ISO	J:164563
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:146040
Biological Process	GO:0046718	viral entry into host cell	ISO	J:155856