GO Annotations Graph

• Symbol: Tnfaip3
• Name: tumor necrosis factor, alpha-induced protein 3
• ID: MGI:1196377

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	ISO	J:164563
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IBA	J:265628
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	ISO	J:164563
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	IBA	J:265628
Molecular Function	GO:0019900	kinase binding	IDA	J:132994
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:169886
Molecular Function	GO:0005515	protein binding	IPI	J:131849
Molecular Function	GO:0005515	protein binding	IPI	J:64942
Molecular Function	GO:0005515	protein binding	IPI	J:286941
Molecular Function	GO:0005515	protein binding	IDA	J:286941
Molecular Function	GO:0005515	protein binding	IPI	J:186074
Molecular Function	GO:0005515	protein binding	IPI	J:176472
Molecular Function	GO:0005515	protein binding	IPI	J:145539
Molecular Function	GO:0005515	protein binding	IPI	J:228302
Molecular Function	GO:0005515	protein binding	IPI	J:160776
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:76628
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0043130	ubiquitin binding	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:64942
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0001922	B-1 B cell homeostasis	IMP	J:170265
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IMP	J:196955
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0007010	cytoskeleton organization	IBA	J:265628
Biological Process	GO:0072666	establishment of protein localization to vacuole	IDA	J:147242
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0002315	marginal zone B cell differentiation	NAS	J:170265
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0010507	negative regulation of autophagy	NAS	J:171790
Biological Process	GO:0050869	negative regulation of B cell activation	IDA	J:170265
Biological Process	GO:2000349	negative regulation of CD40 signaling pathway	ISO	J:164563
Biological Process	GO:0060548	negative regulation of cell death	IMP	J:92931
Biological Process	GO:0002677	negative regulation of chronic inflammatory response	IMP	J:127624
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA	J:169905
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	NAS	J:169905
Biological Process	GO:0002632	negative regulation of granuloma formation	NAS	J:127624
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	NAS	J:169982
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	NAS	J:127624
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:132994
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:170265
Biological Process	GO:0050728	negative regulation of inflammatory response	IDA	J:196955
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:170265
Biological Process	GO:0045824	negative regulation of innate immune response	IMP	J:196955
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	IMP	J:127624
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	IMP	J:132994
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	ISO	J:240614
Biological Process	GO:0032703	negative regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:127624
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:132994
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:170265
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0070429	negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	IMP	J:132994
Biological Process	GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA	J:132994
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	ISO	J:164563
Biological Process	GO:0034148	negative regulation of toll-like receptor 5 signaling pathway	IDA	J:170066
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:170265
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	IDA	J:169905
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0045732	positive regulation of protein catabolic process	IDA	J:147242
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0016579	protein deubiquitination	IDA	J:132994
Biological Process	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0035871	protein K11-linked deubiquitination	ISO	J:164563
Biological Process	GO:0035523	protein K29-linked deubiquitination	IBA	J:265628
Biological Process	GO:1990168	protein K33-linked deubiquitination	IBA	J:265628
Biological Process	GO:0071108	protein K48-linked deubiquitination	ISO	J:164563
Biological Process	GO:0070936	protein K48-linked ubiquitination	ISO	J:164563
Biological Process	GO:0070536	protein K63-linked deubiquitination	ISO	J:164563
Biological Process	GO:0070536	protein K63-linked deubiquitination	IDA	J:208213
Biological Process	GO:0016567	protein ubiquitination	IEA	J:72247
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0002634	regulation of germinal center formation	IMP	J:170265
Biological Process	GO:0002637	regulation of immunoglobulin production	IC	J:170265
Biological Process	GO:0045088	regulation of innate immune response	IC	J:170265
Biological Process	GO:0002237	response to molecule of bacterial origin	ISO	J:164563
Biological Process	GO:0002237	response to molecule of bacterial origin	IDA	J:170066
Biological Process	GO:0032495	response to muramyl dipeptide	IMP	J:132994
Biological Process	GO:0009611	response to wounding	NAS	J:170038
Biological Process	GO:0072573	tolerance induction to lipopolysaccharide	ISO	J:164563