GO Annotations Graph

• Symbol: Top3a
• Name: topoisomerase (DNA) III alpha
• ID: MGI:1197527

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003916	DNA topoisomerase activity	IEA	J:72247
Molecular Function	GO:0003916	DNA topoisomerase activity	IEA	J:60000
Molecular Function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	ISO	J:164563
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0003697	single-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005694	chromosome	IEA	J:72247
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912462
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912487
Cellular Component	GO:0005634	nucleus	NAS	J:319969
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0016605	PML body	ISO	J:164563
Cellular Component	GO:0031422	RecQ family helicase-topoisomerase III complex	ISO	J:164563
Biological Process	GO:0051304	chromosome separation	ISO	J:164563
Biological Process	GO:0006265	DNA topological change	ISO	J:164563
Biological Process	GO:0000724	double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:0032042	mitochondrial DNA metabolic process	ISO	J:164563
Biological Process	GO:0071139	resolution of recombination intermediates	ISO	J:164563