GO Annotations Graph

• Symbol: Shox2
• Name: SHOX homeobox 2
• ID: MGI:1201673

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:241473
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0003209	cardiac atrium morphogenesis	IMP	J:135454
Biological Process	GO:0060920	cardiac pacemaker cell differentiation	IMP	J:146147
Biological Process	GO:0003213	cardiac right atrium morphogenesis	IMP	J:146147
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	IMP	J:107668
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	IMP	J:107668
Biological Process	GO:0002063	chondrocyte development	IMP	J:122558
Biological Process	GO:0002062	chondrocyte differentiation	IMP	J:191689
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	IMP	J:101732
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IMP	J:191689
Biological Process	GO:0030326	embryonic limb morphogenesis	IMP	J:107668
Biological Process	GO:0030326	embryonic limb morphogenesis	IMP	J:122558
Biological Process	GO:0048598	embryonic morphogenesis	IMP	J:101732
Biological Process	GO:0060272	embryonic skeletal joint morphogenesis	IMP	J:138379
Biological Process	GO:0003170	heart valve development	IMP	J:135454
Biological Process	GO:0010463	mesenchymal cell proliferation	IMP	J:138379
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0060415	muscle tissue morphogenesis	IMP	J:170400
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:175381
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:138379
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:138379
Biological Process	GO:0050772	positive regulation of axonogenesis	IMP	J:170400
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IMP	J:138379
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IMP	J:138379
Biological Process	GO:0048743	positive regulation of skeletal muscle fiber development	IMP	J:170400
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	IMP	J:122558
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:138379
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:138379
Biological Process	GO:2000172	regulation of branching morphogenesis of a nerve	IMP	J:170400
Biological Process	GO:0032330	regulation of chondrocyte differentiation	IMP	J:107668
Biological Process	GO:0032330	regulation of chondrocyte differentiation	IMP	J:107668
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0002027	regulation of heart rate	IMP	J:146147
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0060931	sinoatrial node cell development	IMP	J:175381
Biological Process	GO:0003163	sinoatrial node development	IMP	J:146147
Biological Process	GO:0003172	sinoatrial valve development	IMP	J:146147
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:122558
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:122558
Biological Process	GO:0072089	stem cell proliferation	IMP	J:138379