GO Annotations Graph

• Symbol: Atp6v1a
• Name: ATPase, H+ transporting, lysosomal V1 subunit A
• ID: MGI:1201780

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	IEA	J:72245
Molecular Function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	IMP	J:304577
Molecular Function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	IBA	J:265628
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:169877
Cellular Component	GO:1904949	ATPase complex	IDA	J:326652
Cellular Component	GO:0005737	cytoplasm	IDA	J:304577
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:150394
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0098850	extrinsic component of synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005902	microvillus	IDA	J:169877
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:150394
Cellular Component	GO:0033176	proton-transporting V-type ATPase complex	IDA	J:81717
Cellular Component	GO:0033180	proton-transporting V-type ATPase, V1 domain	IDA	J:326652
Cellular Component	GO:0030141	secretory granule	ISO	J:164563
Cellular Component	GO:1902495	transmembrane transporter complex	IDA	J:81717
Cellular Component	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain	ISO	J:164563
Biological Process	GO:0046034	ATP metabolic process	IEA	J:72247
Biological Process	GO:0036295	cellular response to increased oxygen levels	ISO	J:164563
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:1902600	proton transmembrane transport	IBA	J:265628
Biological Process	GO:0097401	synaptic vesicle lumen acidification	IDA	J:326652
Biological Process	GO:0097401	synaptic vesicle lumen acidification	EXP	J:326652
Biological Process	GO:0097401	synaptic vesicle lumen acidification	IMP	J:326652
Biological Process	GO:0097401	synaptic vesicle lumen acidification	IDA	J:326652