GO Annotations Graph

• Symbol: Socs2
• Name: suppressor of cytokine signaling 2
• ID: MGI:1201787

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	IBA	J:265628
Molecular Function	GO:0005131	growth hormone receptor binding	IPI	J:95918
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0008269	JAK pathway signal transduction adaptor activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:280563
Cellular Component	GO:0005737	cytoplasm	IEA	J:72247
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	IBA	J:265628
Biological Process	GO:0032870	cellular response to hormone stimulus	ISO	J:164563
Biological Process	GO:0060396	growth hormone receptor signaling pathway	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IMP	J:95918
Biological Process	GO:0007595	lactation	IMP	J:70408
Biological Process	GO:0007595	lactation	IGI	J:70408
Biological Process	GO:0060749	mammary gland alveolus development	IGI	J:70408
Biological Process	GO:0060749	mammary gland alveolus development	IGI	J:108377
Biological Process	GO:0060749	mammary gland alveolus development	IMP	J:70408
Biological Process	GO:0040015	negative regulation of multicellular organism growth	IMP	J:95918
Biological Process	GO:0040015	negative regulation of multicellular organism growth	IGI	J:95918
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	IGI	J:108377
Biological Process	GO:0009968	negative regulation of signal transduction	IEA	J:60000
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	IBA	J:265628
Biological Process	GO:0045666	positive regulation of neuron differentiation	IDA	J:79885
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IGI	J:108377
Biological Process	GO:0001558	regulation of cell growth	IEA	J:72247
Biological Process	GO:0040008	regulation of growth	IEA	J:60000
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:68342
Biological Process	GO:0032355	response to estradiol	ISO	J:164563