GO Annotations Graph

• Symbol: Socs3
• Name: suppressor of cytokine signaling 3
• ID: MGI:1201791

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	IBA	J:265628
Molecular Function	GO:0035198	miRNA binding	IDA	J:269278
Molecular Function	GO:0035198	miRNA binding	IMP	J:269278
Molecular Function	GO:0001784	phosphotyrosine residue binding	IMP	J:240281
Molecular Function	GO:0005515	protein binding	IPI	J:304576
Molecular Function	GO:0005515	protein binding	IPI	J:168875
Molecular Function	GO:0005515	protein binding	IPI	J:201263
Molecular Function	GO:0005515	protein binding	IPI	J:91027
Molecular Function	GO:0005515	protein binding	IPI	J:94679
Molecular Function	GO:0005515	protein binding	IPI	J:94679
Molecular Function	GO:0005515	protein binding	IPI	J:94679
Molecular Function	GO:0005515	protein binding	IPI	J:94679
Molecular Function	GO:0030292	protein tyrosine kinase inhibitor activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1169194
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2672295
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8955856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9705464
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9705471
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9707972
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9707979
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	IBA	J:265628
Biological Process	GO:0060670	branching involved in labyrinthine layer morphogenesis	IMP	J:70667
Biological Process	GO:0030154	cell differentiation	IGI	J:96515
Biological Process	GO:0030154	cell differentiation	IDA	J:96515
Biological Process	GO:0097398	cellular response to interleukin-17	IDA	J:269278
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0050728	negative regulation of inflammatory response	IGI	J:163717
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	IDA	J:91027
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0009968	negative regulation of signal transduction	IGI	J:96515
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	IBA	J:265628
Biological Process	GO:0060674	placenta blood vessel development	IMP	J:70667
Biological Process	GO:0045597	positive regulation of cell differentiation	IDA	J:96515
Biological Process	GO:0045597	positive regulation of cell differentiation	IGI	J:96515
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	ISO	J:155856
Biological Process	GO:0040008	regulation of growth	IEA	J:60000
Biological Process	GO:0001932	regulation of protein phosphorylation	IDA	J:91027
Biological Process	GO:0007165	signal transduction	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IGI	J:96515
Biological Process	GO:0007165	signal transduction	IGI	J:96515