GO Annotations Graph

• Symbol: Chek1
• Name: checkpoint kinase 1
• ID: MGI:1202065

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0035402	histone H3T11 kinase activity	IDA	J:177150
Molecular Function	GO:0035402	histone H3T11 kinase activity	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:212062
Molecular Function	GO:0005515	protein binding	IPI	J:92518
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:155856
Molecular Function	GO:0004672	protein kinase activity	IMP	J:92518
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:177150
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0000794	condensed nuclear chromosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:71817
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0005657	replication fork	IDA	J:92518
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:1902742	apoptotic process involved in development	IMP	J:62918
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0006338	chromatin remodeling	IDA	J:177150
Biological Process	GO:0000077	DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0000077	DNA damage checkpoint signaling	IMP	J:62919
Biological Process	GO:0000077	DNA damage checkpoint signaling	IDA	J:81636
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IMP	J:177150
Biological Process	GO:0006974	DNA damage response	IDA	J:73858
Biological Process	GO:0006974	DNA damage response	IDA	J:81636
Biological Process	GO:0006281	DNA repair	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IDA	J:92518
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	IMP	J:62919
Biological Process	GO:0001833	inner cell mass cell proliferation	IMP	J:62918
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0007093	mitotic cell cycle checkpoint signaling	IMP	J:62918
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0044818	mitotic G2/M transition checkpoint	ISO	J:164563
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process	ISO	J:155856
Biological Process	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	ISO	J:155856
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	IMP	J:177150
Biological Process	GO:0045839	negative regulation of mitotic nuclear division	ISO	J:164563
Biological Process	GO:0006997	nucleus organization	IMP	J:62918
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045787	positive regulation of cell cycle	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:92518
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:176173
Biological Process	GO:0010569	regulation of double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IGI	J:176173
Biological Process	GO:0046602	regulation of mitotic centrosome separation	ISO	J:164563
Biological Process	GO:0042770	signal transduction in response to DNA damage	ISO	J:164563
Biological Process	GO:0042770	signal transduction in response to DNA damage	ISO	J:155856