GO Annotations Graph

• Symbol: Sorl1
• Name: sortilin-related receptor, LDLR class A repeats-containing
• ID: MGI:1202296

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0030169	low-density lipoprotein particle binding	ISO	J:164563
Molecular Function	GO:0042923	neuropeptide binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:136228
Molecular Function	GO:0005515	protein binding	IPI	J:193410
Molecular Function	GO:0005515	protein binding	IPI	J:228024
Molecular Function	GO:0005515	protein binding	IPI	J:104263
Molecular Function	GO:0005515	protein binding	IPI	J:237133
Molecular Function	GO:0005515	protein binding	IPI	J:149003
Molecular Function	GO:0005515	protein binding	IPI	J:149003
Molecular Function	GO:0005515	protein binding	IPI	J:149003
Molecular Function	GO:0005515	protein binding	IPI	J:149003
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0004888	transmembrane signaling receptor activity	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:285223
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IBA	J:265628
Cellular Component	GO:0031985	Golgi cisterna	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:285223
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005771	multivesicular body	ISO	J:155856
Cellular Component	GO:0005771	multivesicular body	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005641	nuclear envelope lumen	IDA	J:137577
Cellular Component	GO:0005641	nuclear envelope lumen	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:149003
Cellular Component	GO:0097356	perinucleolar compartment	IDA	J:285223
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0055037	recycling endosome	ISO	J:164563
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:164563
Biological Process	GO:1990845	adaptive thermogenesis	IMP	J:228024
Biological Process	GO:0016477	cell migration	ISO	J:155856
Biological Process	GO:0002024	diet induced thermogenesis	IMP	J:228024
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0099638	endosome to plasma membrane protein transport	IDA	J:237133
Biological Process	GO:0038020	insulin receptor recycling	ISO	J:164563
Biological Process	GO:0038020	insulin receptor recycling	IDA	J:237133
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	IMP	J:137577
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	IMP	J:142501
Biological Process	GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IMP	J:137577
Biological Process	GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IMP	J:228024
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IMP	J:137577
Biological Process	GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IMP	J:137577
Biological Process	GO:1902997	negative regulation of neurofibrillary tangle assembly	IMP	J:210074
Biological Process	GO:0050768	negative regulation of neurogenesis	IMP	J:137577
Biological Process	GO:1901215	negative regulation of neuron death	IMP	J:210074
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:1902948	negative regulation of tau-protein kinase activity	IMP	J:210074
Biological Process	GO:0010897	negative regulation of triglyceride catabolic process	IMP	J:237133
Biological Process	GO:0007218	neuropeptide signaling pathway	ISO	J:164563
Biological Process	GO:1904179	positive regulation of adipose tissue development	IMP	J:237133
Biological Process	GO:1904179	positive regulation of adipose tissue development	ISO	J:164563
Biological Process	GO:1902771	positive regulation of choline O-acetyltransferase activity	IMP	J:210074
Biological Process	GO:1902955	positive regulation of early endosome to recycling endosome transport	ISO	J:164563
Biological Process	GO:2001137	positive regulation of endocytic recycling	ISO	J:164563
Biological Process	GO:1902953	positive regulation of ER to Golgi vesicle-mediated transport	ISO	J:164563
Biological Process	GO:1900168	positive regulation of glial cell-derived neurotrophic factor production	ISO	J:164563
Biological Process	GO:1900168	positive regulation of glial cell-derived neurotrophic factor production	IMP	J:276421
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	IMP	J:237133
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0070863	positive regulation of protein exit from endoplasmic reticulum	ISO	J:164563
Biological Process	GO:1902966	positive regulation of protein localization to early endosome	ISO	J:164563
Biological Process	GO:0006892	post-Golgi vesicle-mediated transport	ISO	J:164563
Biological Process	GO:0006892	post-Golgi vesicle-mediated transport	IBA	J:265628
Biological Process	GO:0034067	protein localization to Golgi apparatus	ISO	J:164563
Biological Process	GO:0051604	protein maturation	ISO	J:164563
Biological Process	GO:0045053	protein retention in Golgi apparatus	IMP	J:137577
Biological Process	GO:0045053	protein retention in Golgi apparatus	ISO	J:164563
Biological Process	GO:0045053	protein retention in Golgi apparatus	IBA	J:265628
Biological Process	GO:0006605	protein targeting	ISO	J:164563
Biological Process	GO:0006605	protein targeting	IDA	J:237133
Biological Process	GO:0006622	protein targeting to lysosome	ISO	J:164563
Biological Process	GO:0006622	protein targeting to lysosome	IBA	J:265628
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:0014910	regulation of smooth muscle cell migration	ISO	J:164563