GO Annotations Graph

• Symbol: Itch
• Name: itchy, E3 ubiquitin protein ligase
• ID: MGI:1202301

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:1990763	arrestin family protein binding	ISO	J:164563
Molecular Function	GO:0045236	CXCR chemokine receptor binding	ISO	J:164563
Molecular Function	GO:0016874	ligase activity	IMP	J:131809
Molecular Function	GO:0005515	protein binding	IPI	J:179005
Molecular Function	GO:0005515	protein binding	IPI	J:132213
Molecular Function	GO:0005515	protein binding	IPI	J:314101
Molecular Function	GO:0005515	protein binding	IPI	J:131809
Molecular Function	GO:0005515	protein binding	IPI	J:116617
Molecular Function	GO:0005515	protein binding	IPI	J:284781
Molecular Function	GO:0005515	protein binding	IPI	J:75463
Molecular Function	GO:0043021	ribonucleoprotein complex binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:164563
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:105215
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISA	J:45910
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Cellular Component	GO:0005938	cell cortex	IDA	J:116617
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:89097
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:116617
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2077477
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2077479
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:89097
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:71817
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0000151	ubiquitin ligase complex	ISA	J:45910
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	IMP	J:89097
Biological Process	GO:0051607	defense response to virus	IEA	J:60000
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation	IMP	J:89097
Biological Process	GO:0050687	negative regulation of defense response to virus	ISO	J:164563
Biological Process	GO:0050687	negative regulation of defense response to virus	IMP	J:157738
Biological Process	GO:0046329	negative regulation of JNK cascade	IMP	J:131809
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IMP	J:131809
Biological Process	GO:0045732	positive regulation of protein catabolic process	IMP	J:89097
Biological Process	GO:0045732	positive regulation of protein catabolic process	IDA	J:89097
Biological Process	GO:2000646	positive regulation of receptor catabolic process	ISO	J:164563
Biological Process	GO:0002669	positive regulation of T cell anergy	IMP	J:89097
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:164563
Biological Process	GO:0030163	protein catabolic process	IMP	J:89097
Biological Process	GO:0035519	protein K29-linked ubiquitination	ISO	J:164563
Biological Process	GO:0035519	protein K29-linked ubiquitination	IBA	J:265628
Biological Process	GO:0070936	protein K48-linked ubiquitination	IMP	J:131809
Biological Process	GO:0070936	protein K48-linked ubiquitination	ISO	J:164563
Biological Process	GO:0070936	protein K48-linked ubiquitination	IBA	J:265628
Biological Process	GO:0070534	protein K63-linked ubiquitination	ISO	J:164563
Biological Process	GO:0070534	protein K63-linked ubiquitination	IBA	J:265628
Biological Process	GO:0006513	protein monoubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	IDA	J:89097
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0031623	receptor internalization	ISO	J:164563
Biological Process	GO:0090085	regulation of protein deubiquitination	IMP	J:131809
Biological Process	GO:0002870	T cell anergy	IMP	J:89097
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:105215
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IDA	J:89097
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISA	J:45910
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IDA	J:105215