GO Annotations Graph

• Symbol: Hcrt
• Name: hypocretin
• ID: MGI:1202306

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005184	neuropeptide hormone activity	ISO	J:155856
Molecular Function	GO:0005184	neuropeptide hormone activity	IBA	J:265628
Molecular Function	GO:0031771	type 1 orexin receptor binding	ISO	J:155856
Molecular Function	GO:0031771	type 1 orexin receptor binding	IBA	J:265628
Molecular Function	GO:0031772	type 2 orexin receptor binding	ISO	J:155856
Molecular Function	GO:0031772	type 2 orexin receptor binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:73722
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0042755	eating behavior	ISO	J:155856
Biological Process	GO:0042755	eating behavior	IBA	J:265628
Biological Process	GO:0060079	excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0007631	feeding behavior	IEA	J:72247
Biological Process	GO:0008156	negative regulation of DNA replication	ISO	J:155856
Biological Process	GO:0043267	negative regulation of potassium ion transport	ISO	J:155856
Biological Process	GO:0051970	negative regulation of transmission of nerve impulse	ISO	J:155856
Biological Process	GO:0007218	neuropeptide signaling pathway	IEA	J:60000
Biological Process	GO:0007218	neuropeptide signaling pathway	IEA	J:72247
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0051928	positive regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:262345
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0051971	positive regulation of transmission of nerve impulse	ISO	J:155856
Biological Process	GO:0051971	positive regulation of transmission of nerve impulse	IBA	J:265628
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0046928	regulation of neurotransmitter secretion	ISO	J:155856
Biological Process	GO:0046928	regulation of neurotransmitter secretion	IBA	J:265628
Biological Process	GO:0042594	response to starvation	IBA	J:265628
Biological Process	GO:0030431	sleep	IBA	J:265628
Biological Process	GO:0001659	temperature homeostasis	ISO	J:155856
Biological Process	GO:0001659	temperature homeostasis	IBA	J:265628