GO Annotations Graph

• Symbol: Mmp8
• Name: matrix metallopeptidase 8
• ID: MGI:1202395

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:155856
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0004252	serine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:155856
Cellular Component	GO:0031012	extracellular matrix	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Biological Process	GO:0030574	collagen catabolic process	IBA	J:265628
Biological Process	GO:0030198	extracellular matrix organization	IBA	J:265628
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:265613
Biological Process	GO:0032693	negative regulation of interleukin-10 production	IMP	J:265613
Biological Process	GO:0043388	positive regulation of DNA binding	IMP	J:265613
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:265613
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:265613
Biological Process	GO:0046330	positive regulation of JNK cascade	IMP	J:265613
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:265613
Biological Process	GO:1903980	positive regulation of microglial cell activation	IMP	J:265613
Biological Process	GO:0150078	positive regulation of neuroinflammatory response	ISO	J:155856
Biological Process	GO:0150078	positive regulation of neuroinflammatory response	IMP	J:265613
Biological Process	GO:0150078	positive regulation of neuroinflammatory response	IMP	J:265613
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IMP	J:265613
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	IMP	J:265613
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	IMP	J:265613
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:265613
Biological Process	GO:0030163	protein catabolic process	ISO	J:155856
Biological Process	GO:0006508	proteolysis	ISO	J:164563