GO Annotations Graph

• Symbol: Tcf21
• Name: transcription factor 21
• ID: MGI:1202715

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	ISO	J:164563
Molecular Function	GO:0043425	bHLH transcription factor binding	IPI	J:47702
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:47701
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:69392
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0070888	E-box binding	IDA	J:100397
Molecular Function	GO:0070888	E-box binding	IPI	J:47702
Molecular Function	GO:0042826	histone deacetylase binding	IPI	J:100397
Molecular Function	GO:0050681	nuclear androgen receptor binding	IPI	J:100397
Molecular Function	GO:0005515	protein binding	IPI	J:103507
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IC	J:47701
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:47702
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:64068
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IMP	J:47105
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IMP	J:55785
Biological Process	GO:0014707	branchiomeric skeletal muscle development	IGI	J:111337
Biological Process	GO:0060435	bronchiole development	IMP	J:55785
Biological Process	GO:0032502	developmental process	IBA	J:265628
Biological Process	GO:0060539	diaphragm development	IGI	J:111337
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	ISO	J:155856
Biological Process	GO:0030855	epithelial cell differentiation	IMP	J:55785
Biological Process	GO:0048732	gland development	ISO	J:155856
Biological Process	GO:0032835	glomerulus development	IMP	J:55785
Biological Process	GO:0001822	kidney development	IMP	J:55785
Biological Process	GO:0048286	lung alveolus development	IMP	J:55785
Biological Process	GO:0060425	lung morphogenesis	IMP	J:55785
Biological Process	GO:0060426	lung vasculature development	IMP	J:55785
Biological Process	GO:0072277	metanephric glomerular capillary formation	IMP	J:82211
Biological Process	GO:0072162	metanephric mesenchymal cell differentiation	IMP	J:82211
Biological Process	GO:0001763	morphogenesis of a branching structure	IMP	J:55785
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	IDA	J:100397
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:100397
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:69392
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:47701
Biological Process	GO:0031063	regulation of histone deacetylation	IC	J:100397
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0048608	reproductive structure development	IMP	J:55785
Biological Process	GO:0060541	respiratory system development	IMP	J:55785
Biological Process	GO:0060021	roof of mouth development	IGI	J:111337
Biological Process	GO:0060008	Sertoli cell differentiation	ISO	J:155856
Biological Process	GO:0007530	sex determination	IMP	J:55785
Biological Process	GO:0007548	sex differentiation	IMP	J:92051
Biological Process	GO:0048536	spleen development	IMP	J:64068
Biological Process	GO:0001657	ureteric bud development	IMP	J:55785
Biological Process	GO:0001944	vasculature development	IMP	J:55785