GO Annotations Graph

• Symbol: Myoc
• Name: myocilin
• ID: MGI:1202864

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001968	fibronectin binding	ISO	J:164563
Molecular Function	GO:0005109	frizzled binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0032027	myosin light chain binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:203534
Molecular Function	GO:0005515	protein binding	IPI	J:184367
Molecular Function	GO:0005515	protein binding	IPI	J:147775
Molecular Function	GO:0005515	protein binding	IPI	J:207077
Molecular Function	GO:0005515	protein binding	IPI	J:78796
Molecular Function	GO:0030971	receptor tyrosine kinase binding	IPI	J:203534
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005929	cilium	IEA	J:60000
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:199600
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IDA	J:207077
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:78796
Cellular Component	GO:0005615	extracellular space	ISO	J:121699
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:199600
Cellular Component	GO:0005794	Golgi apparatus	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0097453	mesaxon	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0005758	mitochondrial intermembrane space	ISO	J:164563
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Cellular Component	GO:0035748	myelin sheath abaxonal region	ISO	J:155856
Cellular Component	GO:0033268	node of Ranvier	IDA	J:203534
Cellular Component	GO:0043220	Schmidt-Lanterman incisure	ISO	J:155856
Biological Process	GO:0060348	bone development	IDA	J:199600
Biological Process	GO:0045162	clustering of voltage-gated sodium channels	IMP	J:203534
Biological Process	GO:0038133	ERBB2-ERBB3 signaling pathway	IDA	J:203534
Biological Process	GO:0022011	myelination in peripheral nervous system	IMP	J:203534
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0051497	negative regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0031175	neuron projection development	ISO	J:164563
Biological Process	GO:0038031	non-canonical Wnt signaling pathway via JNK cascade	ISO	J:164563
Biological Process	GO:0001649	osteoblast differentiation	IDA	J:199600
Biological Process	GO:0001649	osteoblast differentiation	ISO	J:164563
Biological Process	GO:0001649	osteoblast differentiation	IBA	J:265628
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:0051901	positive regulation of mitochondrial depolarization	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0001952	regulation of cell-matrix adhesion	IEA	J:72247
Biological Process	GO:0043408	regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0051492	regulation of stress fiber assembly	IEA	J:72247
Biological Process	GO:0007165	signal transduction	IBA	J:265628
Biological Process	GO:0014734	skeletal muscle hypertrophy	IDA	J:184367