GO Annotations Graph

• Symbol: Tcf7l1
• Name: transcription factor 7 like 1 (T cell specific, HMG box)
• ID: MGI:1202876

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	IPI	J:134051
Molecular Function	GO:0008013	beta-catenin binding	IPI	J:45934
Molecular Function	GO:0003682	chromatin binding	IDA	J:138113
Molecular Function	GO:0003682	chromatin binding	IDA	J:134051
Molecular Function	GO:0003682	chromatin binding	IDA	J:134051
Molecular Function	GO:0003682	chromatin binding	IDA	J:134051
Molecular Function	GO:0003677	DNA binding	IDA	J:114674
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:114674
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:134051
Molecular Function	GO:0005515	protein binding	IPI	J:134051
Molecular Function	GO:0005515	protein binding	IPI	J:134051
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:1990907	beta-catenin-TCF complex	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:155012
Cellular Component	GO:0005634	nucleus	IDA	J:134051
Cellular Component	GO:0005634	nucleus	IDA	J:55937
Biological Process	GO:0008595	anterior/posterior axis specification, embryo	IMP	J:90402
Biological Process	GO:0048319	axial mesoderm morphogenesis	IMP	J:90402
Biological Process	GO:0060070	canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0006351	DNA-templated transcription	IDA	J:114674
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:114674
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:99391
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:99391
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:114674
Biological Process	GO:1904672	regulation of somatic stem cell population maintenance	IMP	J:138113
Biological Process	GO:2000036	regulation of stem cell population maintenance	IMP	J:132981
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0043588	skin development	IGI	J:155012
Biological Process	GO:0035019	somatic stem cell population maintenance	IGI	J:155012
Biological Process	GO:0048863	stem cell differentiation	IMP	J:114674
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:99391
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:99391
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:72247