Tcf7l2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
MGI:1202879

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070016	armadillo repeat domain binding	ISO	J:164563
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0008013	beta-catenin binding	IDA	J:152576
Molecular Function	GO:0008013	beta-catenin binding	IPI	J:45934
Molecular Function	GO:0008013	beta-catenin binding	IPI	J:85837
Molecular Function	GO:0008013	beta-catenin binding	IDA	J:50943
Molecular Function	GO:0003682	chromatin binding	IGI	J:198627
Molecular Function	GO:0003682	chromatin binding	IDA	J:127530
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:173152
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0045295	gamma-catenin binding	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0016922	nuclear receptor binding	ISO	J:164563
Molecular Function	GO:0003676	nucleic acid binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:119022
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:188777
Molecular Function	GO:0005515	protein binding	IPI	J:152576
Molecular Function	GO:0005515	protein binding	IPI	J:152576
Molecular Function	GO:0005515	protein binding	IPI	J:173152
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:173152
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:190447
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:193325
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:45934
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:173152
Cellular Component	GO:1990907	beta-catenin-TCF complex	IBA	J:265628
Cellular Component	GO:0070369	beta-catenin-TCF7L2 complex	ISO	J:164563
Cellular Component	GO:0071664	catenin-TCF7L2 complex	IDA	J:45934
Cellular Component	GO:0071664	catenin-TCF7L2 complex	IBA	J:265628
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:137486
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:137486
Cellular Component	GO:0005634	nucleus	IDA	J:190447
Cellular Component	GO:0005634	nucleus	IDA	J:155012
Cellular Component	GO:0005634	nucleus	IDA	J:193325
Cellular Component	GO:0005634	nucleus	IDA	J:173152
Cellular Component	GO:0005634	nucleus	IDA	J:48968
Cellular Component	GO:0005634	nucleus	IDA	J:173152
Cellular Component	GO:0032993	protein-DNA complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:84580
Biological Process	GO:0001568	blood vessel development	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:127546
Biological Process	GO:0030282	bone mineralization	IGI	J:150546
Biological Process	GO:0060070	canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:124680
Biological Process	GO:0060070	canonical Wnt signaling pathway	IDA	J:45934
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:125420
Biological Process	GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0009267	cellular response to starvation	IMP	J:193325
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	IGI	J:90119
Biological Process	GO:0030538	embryonic genitalia morphogenesis	IGI	J:90119
Biological Process	GO:0048619	embryonic hindgut morphogenesis	IGI	J:90119
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:147579
Biological Process	GO:0060325	face morphogenesis	IGI	J:124680
Biological Process	GO:0045444	fat cell differentiation	ISO	J:164563
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IMP	J:127546
Biological Process	GO:0042593	glucose homeostasis	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	IMP	J:190447
Biological Process	GO:0006006	glucose metabolic process	IMP	J:193325
Biological Process	GO:0005977	glycogen metabolic process	IMP	J:193325
Biological Process	GO:0001701	in utero embryonic development	IMP	J:240631
Biological Process	GO:1901142	insulin metabolic process	IMP	J:193325
Biological Process	GO:0001678	intracellular glucose homeostasis	IMP	J:190447
Biological Process	GO:0043570	maintenance of DNA repeat elements	ISO	J:164563
Biological Process	GO:0035264	multicellular organism growth	IMP	J:193325
Biological Process	GO:0048625	myoblast fate commitment	ISO	J:164563
Biological Process	GO:0048625	myoblast fate commitment	IMP	J:125420
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IMP	J:127546
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IMP	J:125420
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	IMP	J:127546
Biological Process	GO:0045721	negative regulation of gluconeogenesis	ISO	J:155856
Biological Process	GO:0046621	negative regulation of organ growth	IMP	J:127546
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:193325
Biological Process	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	ISO	J:155856
Biological Process	GO:0021915	neural tube development	IGI	J:90119
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IGI	J:124680
Biological Process	GO:0014003	oligodendrocyte development	IMP	J:152838
Biological Process	GO:0035265	organ growth	IMP	J:127546
Biological Process	GO:0021983	pituitary gland development	IMP	J:127546
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:127546
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:155182
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:147579
Biological Process	GO:0045722	positive regulation of gluconeogenesis	IMP	J:193325
Biological Process	GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	ISO	J:164563
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:155182
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	IMP	J:193325
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:170886
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:173152
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:98680
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:98680
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:173152
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:193325
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:193325
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process	IMP	J:193325
Biological Process	GO:0009791	post-embryonic development	IMP	J:193325
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:84580
Biological Process	GO:0006111	regulation of gluconeogenesis	IMP	J:190447
Biological Process	GO:0032350	regulation of hormone metabolic process	ISO	J:164563
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:73065
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:155182
Biological Process	GO:0031641	regulation of myelination	IMP	J:152576
Biological Process	GO:0048713	regulation of oligodendrocyte differentiation	IMP	J:152576
Biological Process	GO:0048641	regulation of skeletal muscle tissue development	IMP	J:167712
Biological Process	GO:0048660	regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:155182
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0009749	response to glucose	IMP	J:155182
Biological Process	GO:0032252	secretory granule localization	IMP	J:155182
Biological Process	GO:0043588	skin development	IGI	J:155012
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:52818
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:48968
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:147579
Biological Process	GO:0035019	somatic stem cell population maintenance	IGI	J:155012
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:72247
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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