GO Annotations Graph

• Symbol: Angpt2
• Name: angiopoietin 2
• ID: MGI:1202890

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:46939
Molecular Function	GO:0005515	protein binding	IPI	J:262023
Molecular Function	GO:0048019	receptor antagonist activity	TAS	J:262023
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0030971	receptor tyrosine kinase binding	IBA	J:265628
Molecular Function	GO:0005172	vascular endothelial growth factor receptor binding	TAS	J:53333
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Biological Process	GO:0001525	angiogenesis	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IGI	J:109722
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:94974
Biological Process	GO:0001974	blood vessel remodeling	TAS	J:169941
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0007492	endoderm development	TAS	J:53333
Biological Process	GO:0010467	gene expression	ISO	J:262023
Biological Process	GO:0072012	glomerulus vasculature development	ISO	J:155856
Biological Process	GO:0030097	hemopoiesis	TAS	J:169941
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0016525	negative regulation of angiogenesis	IDA	J:46939
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	IDA	J:51336
Biological Process	GO:0050928	negative regulation of positive chemotaxis	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0045765	regulation of angiogenesis	TAS	J:169941
Biological Process	GO:0048014	Tie signaling pathway	TAS	J:169941
Biological Process	GO:0048014	Tie signaling pathway	ISO	J:164563
Biological Process	GO:0048014	Tie signaling pathway	IBA	J:265628
Biological Process	GO:0048014	Tie signaling pathway	TAS	J:262023
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	J:4639