GO Annotations Graph

• Symbol: Sema6a
• Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
• ID: MGI:1203727

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0045499	chemorepellent activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	IPI	J:180544
Molecular Function	GO:0042802	identical protein binding	IPI	J:180543
Molecular Function	GO:0005515	protein binding	IPI	J:163378
Molecular Function	GO:0005515	protein binding	IPI	J:66237
Molecular Function	GO:0005515	protein binding	IPI	J:180544
Molecular Function	GO:0005515	protein binding	IPI	J:180543
Molecular Function	GO:0030215	semaphorin receptor binding	IBA	J:265628
Molecular Function	GO:0030215	semaphorin receptor binding	IGI	J:135408
Molecular Function	GO:0030215	semaphorin receptor binding	IPI	J:135408
Molecular Function	GO:0030215	semaphorin receptor binding	IPI	J:98330
Molecular Function	GO:0030215	semaphorin receptor binding	IGI	J:135408
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IMP	J:180544
Cellular Component	GO:0030424	axon	NAS	J:66237
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	NAS	J:66237
Cellular Component	GO:0005886	plasma membrane	IDA	J:180544
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2045917
Biological Process	GO:0006915	apoptotic process	NAS	J:66237
Biological Process	GO:0007411	axon guidance	IMP	J:102514
Biological Process	GO:0007411	axon guidance	NAS	J:66237
Biological Process	GO:0007411	axon guidance	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:135408
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0051642	centrosome localization	IMP	J:135408
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0050919	negative chemotaxis	IBA	J:265628
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	IBA	J:265628
Biological Process	GO:0106089	negative regulation of cell adhesion involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	ISO	J:164563
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0001755	neural crest cell migration	IBA	J:265628
Biological Process	GO:0001764	neuron migration	IMP	J:102514
Biological Process	GO:2001224	positive regulation of neuron migration	IMP	J:180544
Biological Process	GO:2001224	positive regulation of neuron migration	IBA	J:265628
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IMP	J:180544
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IBA	J:265628