GO Annotations Graph

• Symbol: Nkx6-1
• Name: NK6 homeobox 1
• ID: MGI:1206039

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TAS	J:65512
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-186524
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:104307
Cellular Component	GO:0005634	nucleus	IDA	J:130846
Cellular Component	GO:0005634	nucleus	IDA	J:127471
Cellular Component	GO:0005634	nucleus	IDA	J:86307
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0008283	cell population proliferation	ISO	J:155856
Biological Process	GO:0021953	central nervous system neuron differentiation	IMP	J:152847
Biological Process	GO:0031018	endocrine pancreas development	IMP	J:98770
Biological Process	GO:0031018	endocrine pancreas development	IGI	J:98770
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	IGI	J:98428
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0022008	neurogenesis	ISO	J:155856
Biological Process	GO:0030182	neuron differentiation	IDA	J:133641
Biological Process	GO:0030182	neuron differentiation	IDA	J:133641
Biological Process	GO:0001764	neuron migration	IEA	J:72247
Biological Process	GO:0048709	oligodendrocyte differentiation	IGI	J:95822
Biological Process	GO:0048709	oligodendrocyte differentiation	IGI	J:98428
Biological Process	GO:0048709	oligodendrocyte differentiation	IGI	J:98428
Biological Process	GO:0003310	pancreatic A cell differentiation	IGI	J:98770
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0045666	positive regulation of neuron differentiation	IDA	J:133641
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	IGI	J:98428
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	IGI	J:98428
Biological Process	GO:0030516	regulation of axon extension	IMP	J:152847
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0050796	regulation of insulin secretion	IEA	J:72247
Biological Process	GO:2001222	regulation of neuron migration	IMP	J:152847
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:156172
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:71607
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IGI	J:71607
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:156172
Biological Process	GO:0007224	smoothened signaling pathway	IDA	J:138713
Biological Process	GO:0006366	transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0003309	type B pancreatic cell differentiation	IMP	J:98770
Biological Process	GO:0044342	type B pancreatic cell proliferation	ISO	J:155856