Pik3ca GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
MGI:1206581

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	ISO	J:155856
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	ISO	J:164563
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	IBA	J:265628
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	IMP	J:158739
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	IDA	J:125968
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	IMP	J:327397
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	IDA	J:87902
Molecular Function	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0043560	insulin receptor substrate binding	IPI	J:109204
Molecular Function	GO:0043560	insulin receptor substrate binding	IPI	J:109204
Molecular Function	GO:0016301	kinase activity	ISO	J:217701
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0035004	phosphatidylinositol 3-kinase activity	IEA	J:72247
Molecular Function	GO:0052812	phosphatidylinositol-3,4-bisphosphate 5-kinase activity	IEA	J:72245
Molecular Function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IEA	J:72245
Molecular Function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS	Reactome:R-NUL-9616944
Molecular Function	GO:0005515	protein binding	IPI	J:292538
Molecular Function	GO:0005515	protein binding	IPI	J:136236
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:122866
Molecular Function	GO:0005515	protein binding	IPI	J:239186
Molecular Function	GO:0005515	protein binding	IPI	J:36742
Molecular Function	GO:0030295	protein kinase activator activity	IDA	J:173141
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IMP	J:158739
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IDA	J:125968
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IMP	J:327397
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027268
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9031553
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9031077
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9603412
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9616944
Cellular Component	GO:0014704	intercalated disc	IDA	J:292538
Cellular Component	GO:0030027	lamellipodium	IDA	J:87902
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	ISO	J:155856
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	IPI	J:36742
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	ISO	J:164563
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	IBA	J:265628
Cellular Component	GO:0005944	phosphatidylinositol 3-kinase complex, class IB	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0030036	actin cytoskeleton organization	IMP	J:292538
Biological Process	GO:0060612	adipose tissue development	IMP	J:213164
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0086003	cardiac muscle cell contraction	IMP	J:292538
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0071333	cellular response to glucose stimulus	IMP	J:213164
Biological Process	GO:0071464	cellular response to hydrostatic pressure	IMP	J:292538
Biological Process	GO:0097009	energy homeostasis	IMP	J:213164
Biological Process	GO:0006006	glucose metabolic process	IMP	J:109024
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:158739
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:125968
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IMP	J:327397
Biological Process	GO:0001889	liver development	IMP	J:213164
Biological Process	GO:0030835	negative regulation of actin filament depolymerization	IMP	J:292538
Biological Process	GO:2000811	negative regulation of anoikis	ISO	J:164563
Biological Process	GO:2000270	negative regulation of fibroblast apoptotic process	IDA	J:91529
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:84857
Biological Process	GO:0006909	phagocytosis	IEA	J:60000
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IMP	J:292538
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	ISO	J:155856
Biological Process	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	IBA	J:265628
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	IEA	J:72247
Biological Process	GO:0016310	phosphorylation	ISO	J:217701
Biological Process	GO:0044029	positive regulation of gene expression via CpG island demethylation	IDA	J:173141
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA	J:173141
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:285299
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:109024
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:109024
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:109024
Biological Process	GO:0110053	regulation of actin filament organization	IMP	J:292538
Biological Process	GO:0043457	regulation of cellular respiration	IMP	J:213164
Biological Process	GO:0010468	regulation of gene expression	IMP	J:146128
Biological Process	GO:2000653	regulation of genetic imprinting	IDA	J:173141
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:109024
Biological Process	GO:0001932	regulation of protein phosphorylation	IDA	J:91529
Biological Process	GO:0055119	relaxation of cardiac muscle	IMP	J:292538
Biological Process	GO:0035994	response to muscle stretch	IMP	J:292538
Biological Process	GO:0038203	TORC2 signaling	ISO	J:285299
Biological Process	GO:0038084	vascular endothelial growth factor signaling pathway	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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