GO Annotations Graph

• Symbol: Casp8
• Name: caspase 8
• ID: MGI:1261423

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IMP	J:281456
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	ISO	J:155856
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IMP	J:285930
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:268622
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IGI	J:170814
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:93322
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:285926
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	IDA	J:78954
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	IDA	J:101402
Molecular Function	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO	J:164563
Molecular Function	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IBA	J:265628
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:72247
Molecular Function	GO:0035877	death effector domain binding	ISO	J:164563
Molecular Function	GO:0035877	death effector domain binding	IBA	J:265628
Molecular Function	GO:0005123	death receptor binding	ISO	J:155856
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:297419
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:180684
Molecular Function	GO:0004175	endopeptidase activity	IMP	J:180684
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	IMP	J:103506
Molecular Function	GO:0008233	peptidase activity	IDA	J:70549
Molecular Function	GO:0005515	protein binding	IPI	J:279494
Molecular Function	GO:0005515	protein binding	IPI	J:139785
Molecular Function	GO:0005515	protein binding	IPI	J:226752
Molecular Function	GO:0005515	protein binding	IPI	J:171939
Molecular Function	GO:0005515	protein binding	IPI	J:114810
Molecular Function	GO:0005515	protein binding	IPI	J:248272
Molecular Function	GO:0005515	protein binding	IPI	J:265780
Molecular Function	GO:0005515	protein binding	IPI	J:209137
Molecular Function	GO:0005515	protein binding	IPI	J:200418
Molecular Function	GO:0005515	protein binding	IPI	J:200420
Molecular Function	GO:0005515	protein binding	IPI	J:217283
Molecular Function	GO:0005515	protein binding	IPI	J:228302
Molecular Function	GO:0005515	protein binding	IPI	J:170814
Molecular Function	GO:0005515	protein binding	IPI	J:72719
Molecular Function	GO:0005515	protein binding	IPI	J:205986
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0008303	caspase complex	ISO	J:164563
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	ISO	J:155856
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	ISO	J:164563
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:59337
Cellular Component	GO:0005737	cytoplasm	NAS	J:320293
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:78954
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0031264	death-inducing signaling complex	ISO	J:155856
Cellular Component	GO:0031264	death-inducing signaling complex	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0030690	Noc1p-Noc2p complex	IMP	J:87073
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:78954
Cellular Component	GO:0005886	plasma membrane	IDA	J:59337
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0097342	ripoptosome	ISO	J:164563
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	ISO	J:164563
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	NAS	J:320292
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA	J:265628
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	J:78039
Biological Process	GO:0001525	angiogenesis	IMP	J:285930
Biological Process	GO:0001525	angiogenesis	IMP	J:103506
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	ISO	J:73065
Biological Process	GO:0006915	apoptotic process	IDA	J:101402
Biological Process	GO:0097190	apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0097190	apoptotic signaling pathway	IDA	J:101402
Biological Process	GO:0048738	cardiac muscle tissue development	TAS	J:180458
Biological Process	GO:0097194	execution phase of apoptosis	ISO	J:164563
Biological Process	GO:0097194	execution phase of apoptosis	IMP	J:214394
Biological Process	GO:0097194	execution phase of apoptosis	IMP	J:214393
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IMP	J:285930
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IGI	J:202809
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IDA	J:78954
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IGI	J:196028
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IDA	J:113782
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IGI	J:196028
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	NAS	J:170815
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IBA	J:265628
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IMP	J:92722
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IMP	J:92722
Biological Process	GO:0007507	heart development	IMP	J:285930
Biological Process	GO:0007507	heart development	IMP	J:103506
Biological Process	GO:0097284	hepatocyte apoptotic process	IMP	J:92722
Biological Process	GO:0030225	macrophage differentiation	TAS	J:180458
Biological Process	GO:0030225	macrophage differentiation	IBA	J:265628
Biological Process	GO:0030225	macrophage differentiation	IMP	J:92722
Biological Process	GO:0070266	necroptotic process	IGI	J:170814
Biological Process	GO:0070266	necroptotic process	IGI	J:180684
Biological Process	GO:0070266	necroptotic process	IGI	J:177328
Biological Process	GO:0070266	necroptotic process	IGI	J:170814
Biological Process	GO:0070266	necroptotic process	IGI	J:180684
Biological Process	GO:0070266	necroptotic process	IGI	J:170814
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0060546	negative regulation of necroptotic process	IMP	J:281456
Biological Process	GO:0060546	negative regulation of necroptotic process	ISO	J:164563
Biological Process	GO:0060546	negative regulation of necroptotic process	IMP	J:285926
Biological Process	GO:0060546	negative regulation of necroptotic process	IMP	J:285930
Biological Process	GO:0060546	negative regulation of necroptotic process	IGI	J:202809
Biological Process	GO:0060546	negative regulation of necroptotic process	IGI	J:177328
Biological Process	GO:0060546	negative regulation of necroptotic process	IGI	J:170814
Biological Process	GO:0060546	negative regulation of necroptotic process	IGI	J:180684
Biological Process	GO:0060546	negative regulation of necroptotic process	IGI	J:170814
Biological Process	GO:0060546	negative regulation of necroptotic process	IGI	J:170814
Biological Process	GO:0060546	negative regulation of necroptotic process	IGI	J:180684
Biological Process	GO:0001841	neural tube formation	IMP	J:103506
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:214394
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:214393
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:47358
Biological Process	GO:0043065	positive regulation of apoptotic process	IDA	J:47358
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IGI	J:101402
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0045651	positive regulation of macrophage differentiation	ISO	J:164563
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:0045862	positive regulation of proteolysis	ISO	J:164563
Biological Process	GO:0051604	protein maturation	ISO	J:164563
Biological Process	GO:0016485	protein processing	IDA	J:268622
Biological Process	GO:0016485	protein processing	ISO	J:155856
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	IDA	J:297419
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	ISO	J:164563
Biological Process	GO:0070269	pyroptosis	IDA	J:268622
Biological Process	GO:0070269	pyroptosis	IMP	J:285930
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:2001233	regulation of apoptotic signaling pathway	IGI	J:93322
Biological Process	GO:0001817	regulation of cytokine production	IDA	J:297419
Biological Process	GO:0045088	regulation of innate immune response	IDA	J:297419
Biological Process	GO:0070243	regulation of thymocyte apoptotic process	IGI	J:93322
Biological Process	GO:0045471	response to ethanol	ISO	J:155856
Biological Process	GO:0034612	response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0097264	self proteolysis	IMP	J:281456
Biological Process	GO:0036462	TRAIL-activated apoptotic signaling pathway	ISO	J:164563