GO Annotations Graph

• Symbol: Drosha
• Name: drosha, ribonuclease type III
• ID: MGI:1261425

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0017151	DEAD/H-box RNA helicase binding	ISO	J:164563
Molecular Function	GO:0004519	endonuclease activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0001530	lipopolysaccharide binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0070878	primary miRNA binding	ISO	J:164563
Molecular Function	GO:0070878	primary miRNA binding	IDA	J:258363
Molecular Function	GO:0005515	protein binding	IPI	J:152729
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0070412	R-SMAD binding	ISO	J:164563
Molecular Function	GO:0004525	ribonuclease III activity	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0003723	RNA binding	IEA	J:72247
Molecular Function	GO:0004521	RNA endonuclease activity	IDA	J:161968
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0003735	structural constituent of ribosome	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:190566
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:190566
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:190566
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:190566
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:190566
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:190566
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:190566
Cellular Component	GO:0070877	microprocessor complex	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0014069	postsynaptic density	IDA	J:190566
Cellular Component	GO:0014069	postsynaptic density	IDA	J:190566
Cellular Component	GO:0014069	postsynaptic density	IEP	J:190566
Cellular Component	GO:0014069	postsynaptic density	IDA	J:190566
Cellular Component	GO:0014069	postsynaptic density	IPI	J:190566
Cellular Component	GO:0014069	postsynaptic density	IDA	J:190566
Cellular Component	GO:0014069	postsynaptic density	IDA	J:190566
Cellular Component	GO:0014069	postsynaptic density	IPI	J:190566
Biological Process	GO:0050829	defense response to Gram-negative bacterium	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	ISO	J:164563
Biological Process	GO:0010586	miRNA metabolic process	IMP	J:161968
Biological Process	GO:0070125	mitochondrial translational elongation	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:197739
Biological Process	GO:0031054	pre-miRNA processing	IDA	J:152654
Biological Process	GO:0031053	primary miRNA processing	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IMP	J:177504
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:138683
Biological Process	GO:2000628	regulation of miRNA metabolic process	IMP	J:197739
Biological Process	GO:0045589	regulation of regulatory T cell differentiation	IMP	J:138683
Biological Process	GO:0042254	ribosome biogenesis	IEA	J:60000
Biological Process	GO:0006396	RNA processing	IEA	J:72247
Biological Process	GO:0006364	rRNA processing	IEA	J:72247