GO Annotations Graph

• Symbol: Endog
• Name: endonuclease G
• ID: MGI:1261433

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004520	DNA endonuclease activity	IDA	J:314088
Molecular Function	GO:0004520	DNA endonuclease activity	IMP	J:313852
Molecular Function	GO:0004520	DNA endonuclease activity	ISO	J:164563
Molecular Function	GO:0004520	DNA endonuclease activity	IMP	J:218272
Molecular Function	GO:0004536	DNA nuclease activity	ISO	J:155856
Molecular Function	GO:0004519	endonuclease activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:72247
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:314088
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:313852
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:301224
Molecular Function	GO:0042803	protein homodimerization activity	IMP	J:313852
Molecular Function	GO:0004521	RNA endonuclease activity	IBA	J:265628
Molecular Function	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Biological Process	GO:0006309	apoptotic DNA fragmentation	IBA	J:265628
Biological Process	GO:0006309	apoptotic DNA fragmentation	IMP	J:88144
Biological Process	GO:0006309	apoptotic DNA fragmentation	IMP	J:88144
Biological Process	GO:0006308	DNA catabolic process	TAS	J:180458
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0001701	in utero embryonic development	IMP	J:88144
Biological Process	GO:0001701	in utero embryonic development	IMP	J:88144
Biological Process	GO:0032043	mitochondrial DNA catabolic process	ISO	J:164563
Biological Process	GO:0032007	negative regulation of TOR signaling	IMP	J:301224
Biological Process	GO:0032007	negative regulation of TOR signaling	ISO	J:164563
Biological Process	GO:1902512	positive regulation of apoptotic DNA fragmentation	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	TAS	J:180458
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:88144
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:88144
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	IMP	J:301224
Biological Process	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death	ISO	J:155856
Biological Process	GO:0090297	positive regulation of mitochondrial DNA replication	ISO	J:164563
Biological Process	GO:0046677	response to antibiotic	IMP	J:88144
Biological Process	GO:0046677	response to antibiotic	IMP	J:88144
Biological Process	GO:0034612	response to tumor necrosis factor	IMP	J:88144
Biological Process	GO:0034612	response to tumor necrosis factor	IMP	J:88144