GO Annotations Graph

• Symbol: Dnmt3a
• Name: DNA methyltransferase 3A
• ID: MGI:1261827

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	IDA	J:104088
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	ISO	J:164563
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	IBA	J:265628
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	IDA	J:48528
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	IGI	J:128981
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	IDA	J:72444
Molecular Function	GO:0051719	DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates	TAS	Reactome:R-MMU-5336316
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:72444
Molecular Function	GO:0009008	DNA-methyltransferase activity	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008168	methyltransferase activity	TAS	J:75938
Molecular Function	GO:0005515	protein binding	IPI	J:245372
Molecular Function	GO:0005515	protein binding	IPI	J:150923
Molecular Function	GO:0005515	protein binding	IPI	J:150923
Molecular Function	GO:0005515	protein binding	IPI	J:245277
Molecular Function	GO:0005515	protein binding	IPI	J:123743
Molecular Function	GO:0005515	protein binding	IPI	J:206847
Molecular Function	GO:0005515	protein binding	IPI	J:266270
Molecular Function	GO:0005515	protein binding	IPI	J:200300
Molecular Function	GO:0005515	protein binding	IPI	J:295943
Molecular Function	GO:0005515	protein binding	IPI	J:128981
Molecular Function	GO:0005515	protein binding	IPI	J:104088
Molecular Function	GO:0005515	protein binding	IPI	J:188023
Molecular Function	GO:0106363	protein-cysteine methyltransferase activity	IDA	J:193011
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:1902494	catalytic complex	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000775	chromosome, centromeric region	IDA	J:93321
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:97081
Cellular Component	GO:0005737	cytoplasm	IDA	J:97081
Cellular Component	GO:0000791	euchromatin	ISO	J:164563
Cellular Component	GO:0000792	heterochromatin	IDA	J:104088
Cellular Component	GO:0000792	heterochromatin	IDA	J:75938
Cellular Component	GO:0016363	nuclear matrix	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-4655387
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5334134
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5336316
Cellular Component	GO:0005634	nucleus	IDA	J:150923
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:163018
Cellular Component	GO:0001741	XY body	IDA	J:163018
Biological Process	GO:0090116	C-5 methylation of cytosine	ISO	J:164563
Biological Process	GO:0071230	cellular response to amino acid stimulus	IDA	J:164409
Biological Process	GO:1903926	cellular response to bisphenol A	IDA	J:310324
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006306	DNA methylation	ISO	J:164563
Biological Process	GO:0006306	DNA methylation	IGI	J:128981
Biological Process	GO:0006306	DNA methylation	IGI	J:261327
Biological Process	GO:0006306	DNA methylation	IDA	J:72444
Biological Process	GO:0006306	DNA methylation	IDA	J:75938
Biological Process	GO:0043045	DNA methylation involved in embryo development	IMP	J:91108
Biological Process	GO:0043045	DNA methylation involved in embryo development	IGI	J:58298
Biological Process	GO:0043045	DNA methylation involved in embryo development	IGI	J:261327
Biological Process	GO:0043045	DNA methylation involved in embryo development	IMP	J:173432
Biological Process	GO:0043046	DNA methylation involved in gamete generation	IMP	J:91108
Biological Process	GO:0032776	DNA methylation on cytosine	ISO	J:155856
Biological Process	GO:0032776	DNA methylation on cytosine	IBA	J:265628
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	IGI	J:128981
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	IGI	J:128981
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	IDA	J:104088
Biological Process	GO:0032259	methylation	IEA	J:60000
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IBA	J:265628
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	TAS	J:173141
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	IDA	J:173141
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:104088
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0010468	regulation of gene expression	IEA	J:72247
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	IDA	J:173141
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	IMP	J:91108
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	IMP	J:91108
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	IMP	J:75938
Biological Process	GO:0007283	spermatogenesis	IMP	J:75938