GO Annotations Graph

• Symbol: Cry1
• Name: cryptochrome circadian regulator 1
• ID: MGI:1270841

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IBA	J:265628
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:209477
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:51295
Molecular Function	GO:0070888	E-box binding	IDA	J:176743
Molecular Function	GO:0070888	E-box binding	IDA	J:205586
Molecular Function	GO:0070888	E-box binding	IDA	J:173042
Molecular Function	GO:0070888	E-box binding	IDA	J:192252
Molecular Function	GO:0071949	FAD binding	IBA	J:265628
Molecular Function	GO:0042826	histone deacetylase binding	IPI	J:209491
Molecular Function	GO:0019900	kinase binding	IPI	J:207239
Molecular Function	GO:0016922	nuclear receptor binding	IPI	J:179376
Molecular Function	GO:0016922	nuclear receptor binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0019902	phosphatase binding	ISO	J:164563
Molecular Function	GO:0009881	photoreceptor activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:266073
Molecular Function	GO:0005515	protein binding	IPI	J:179376
Molecular Function	GO:0005515	protein binding	IPI	J:196293
Molecular Function	GO:0005515	protein binding	IPI	J:200473
Molecular Function	GO:0005515	protein binding	IPI	J:268088
Molecular Function	GO:0005515	protein binding	IPI	J:196684
Molecular Function	GO:0005515	protein binding	IPI	J:167924
Molecular Function	GO:0005515	protein binding	IPI	J:139296
Molecular Function	GO:0005515	protein binding	IPI	J:139296
Molecular Function	GO:0005515	protein binding	IPI	J:122872
Molecular Function	GO:0005515	protein binding	IPI	J:227468
Molecular Function	GO:0005515	protein binding	IPI	J:116444
Molecular Function	GO:0005515	protein binding	IPI	J:122872
Molecular Function	GO:0005515	protein binding	IPI	J:194037
Molecular Function	GO:0005515	protein binding	IPI	J:194037
Molecular Function	GO:0005515	protein binding	IPI	J:209425
Molecular Function	GO:0005515	protein binding	IPI	J:209570
Molecular Function	GO:0005515	protein binding	IPI	J:194037
Molecular Function	GO:0005515	protein binding	IPI	J:245577
Molecular Function	GO:0005515	protein binding	IPI	J:111071
Molecular Function	GO:0005515	protein binding	IPI	J:130591
Molecular Function	GO:0005515	protein binding	IPI	J:213876
Molecular Function	GO:0005515	protein binding	IPI	J:196293
Molecular Function	GO:0005515	protein binding	IPI	J:283196
Molecular Function	GO:0005515	protein binding	IPI	J:244975
Molecular Function	GO:0005515	protein binding	IPI	J:209477
Molecular Function	GO:0005515	protein binding	IPI	J:209570
Molecular Function	GO:0005515	protein binding	IPI	J:173042
Molecular Function	GO:0005515	protein binding	IPI	J:255965
Molecular Function	GO:0005515	protein binding	IPI	J:130591
Molecular Function	GO:0005515	protein binding	IPI	J:210023
Molecular Function	GO:0005515	protein binding	IPI	J:245363
Molecular Function	GO:0005515	protein binding	IPI	J:227468
Molecular Function	GO:0005515	protein binding	IPI	J:143808
Molecular Function	GO:0005515	protein binding	IPI	J:143808
Molecular Function	GO:0005515	protein binding	IPI	J:196684
Molecular Function	GO:0005515	protein binding	IPI	J:245363
Molecular Function	GO:0005515	protein binding	IPI	J:209491
Molecular Function	GO:0005515	protein binding	IPI	J:87576
Molecular Function	GO:0005515	protein binding	IPI	J:196293
Molecular Function	GO:0005515	protein binding	IPI	J:240095
Molecular Function	GO:0005515	protein binding	IPI	J:192252
Molecular Function	GO:0005515	protein binding	IPI	J:156994
Molecular Function	GO:0005515	protein binding	IPI	J:212062
Molecular Function	GO:0005515	protein binding	IPI	J:194037
Molecular Function	GO:0005515	protein binding	IPI	J:210938
Molecular Function	GO:0005515	protein binding	IPI	J:326904
Molecular Function	GO:0019901	protein kinase binding	IPI	J:153754
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1856952
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-508627
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-549359
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-549451
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-549498
Cellular Component	GO:0005739	mitochondrion	IDA	J:51295
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-508640
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-508741
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-517959
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-549498
Cellular Component	GO:0005634	nucleus	IDA	J:212062
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:209425
Cellular Component	GO:0005634	nucleus	IDA	J:245577
Cellular Component	GO:0005634	nucleus	IDA	J:173042
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:85423
Cellular Component	GO:0005634	nucleus	IDA	J:71817
Cellular Component	GO:0005634	nucleus	IDA	J:78197
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:192252
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:205586
Biological Process	GO:0032922	circadian regulation of gene expression	IGI	J:179376
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:196953
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:147991
Biological Process	GO:0032922	circadian regulation of gene expression	IBA	J:265628
Biological Process	GO:0007623	circadian rhythm	IEP	J:192252
Biological Process	GO:0007623	circadian rhythm	IMP	J:273529
Biological Process	GO:0007623	circadian rhythm	IMP	J:76640
Biological Process	GO:0007623	circadian rhythm	IDA	J:84471
Biological Process	GO:0007623	circadian rhythm	IMP	J:119742
Biological Process	GO:0043153	entrainment of circadian clock by photoperiod	IMP	J:196953
Biological Process	GO:0043153	entrainment of circadian clock by photoperiod	IBA	J:265628
Biological Process	GO:0006094	gluconeogenesis	IMP	J:209480
Biological Process	GO:0042593	glucose homeostasis	IGI	J:179376
Biological Process	GO:0019915	lipid storage	IGI	J:198214
Biological Process	GO:0042754	negative regulation of circadian rhythm	IMP	J:204645
Biological Process	GO:0042754	negative regulation of circadian rhythm	IDA	J:154880
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:176743
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:205586
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:244975
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:255965
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:213082
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:211236
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:206921
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:204645
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IGI	J:179376
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:215866
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:154880
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:135812
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IBA	J:265628
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	IMP	J:209480
Biological Process	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	IDA	J:209461
Biological Process	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	IGI	J:179376
Biological Process	GO:2000850	negative regulation of glucocorticoid secretion	IGI	J:198214
Biological Process	GO:0045721	negative regulation of gluconeogenesis	IMP	J:266073
Biological Process	GO:0045721	negative regulation of gluconeogenesis	IMP	J:245577
Biological Process	GO:0031397	negative regulation of protein ubiquitination	IDA	J:210938
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:209480
Biological Process	GO:0045722	positive regulation of gluconeogenesis	IDA	J:266073
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IMP	J:245577
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:243464
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:170767
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:153754
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:209472
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:54241
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:196953
Biological Process	GO:2000001	regulation of DNA damage checkpoint	IDA	J:209425
Biological Process	GO:0006111	regulation of gluconeogenesis	IMP	J:266073
Biological Process	GO:0006111	regulation of gluconeogenesis	IEP	J:266073
Biological Process	GO:0014823	response to activity	IMP	J:255965
Biological Process	GO:0033762	response to glucagon	IMP	J:209480
Biological Process	GO:0032868	response to insulin	IGI	J:198214
Biological Process	GO:0009416	response to light stimulus	IMP	J:273529
Biological Process	GO:0050896	response to stimulus	IEA	J:60000
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0061912	selective autophagy	IMP	J:266073
Biological Process	GO:0061912	selective autophagy	IPI	J:266073
Biological Process	GO:0042770	signal transduction in response to DNA damage	IDA	J:209425