GO Annotations Graph

• Symbol: Gck
• Name: glucokinase
• ID: MGI:1270854

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043531	ADP binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0008865	fructokinase activity	ISO	J:155856
Molecular Function	GO:0008865	fructokinase activity	IBA	J:265628
Molecular Function	GO:0004340	glucokinase activity	ISO	J:155856
Molecular Function	GO:0004340	glucokinase activity	IMP	J:189544
Molecular Function	GO:0004340	glucokinase activity	ISO	J:164563
Molecular Function	GO:0004340	glucokinase activity	IMP	J:281200
Molecular Function	GO:0004340	glucokinase activity	IBA	J:265628
Molecular Function	GO:0004340	glucokinase activity	TAS	J:63850
Molecular Function	GO:0004340	glucokinase activity	IMP	J:28756
Molecular Function	GO:0004340	glucokinase activity	IDA	J:8051
Molecular Function	GO:0004340	glucokinase activity	IDA	J:61183
Molecular Function	GO:0004340	glucokinase activity	IDA	J:115233
Molecular Function	GO:0004340	glucokinase activity	IMP	J:43906
Molecular Function	GO:0004340	glucokinase activity	IMP	J:109919
Molecular Function	GO:0004340	glucokinase activity	IMP	J:29415
Molecular Function	GO:0004340	glucokinase activity	IDA	J:5824
Molecular Function	GO:0005536	glucose binding	ISO	J:155856
Molecular Function	GO:0005536	glucose binding	ISO	J:164563
Molecular Function	GO:0004396	hexokinase activity	IDA	J:30334
Molecular Function	GO:0004396	hexokinase activity	IMP	J:219178
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:155856
Molecular Function	GO:0019158	mannokinase activity	ISO	J:155856
Molecular Function	GO:0019158	mannokinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:133563
Molecular Function	GO:0005515	protein binding	IPI	J:85083
Molecular Function	GO:0005515	protein binding	IPI	J:85083
Molecular Function	GO:0005515	protein binding	IPI	J:85083
Molecular Function	GO:0005515	protein binding	IPI	J:85083
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005884	actin filament	ISO	J:155856
Cellular Component	GO:0045180	basal cortex	ISO	J:155856
Cellular Component	GO:0005938	cell cortex	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-186510
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9625102
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:207233
Cellular Component	GO:0005829	cytosol	IDA	J:207233
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:85083
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005654	nucleoplasm	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:61183
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:207233
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Biological Process	GO:0070509	calcium ion import	IMP	J:141688
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:72247
Biological Process	GO:0046835	carbohydrate phosphorylation	IMP	J:109919
Biological Process	GO:0046835	carbohydrate phosphorylation	ISO	J:155856
Biological Process	GO:0046835	carbohydrate phosphorylation	IBA	J:265628
Biological Process	GO:0046835	carbohydrate phosphorylation	IDA	J:8051
Biological Process	GO:0046835	carbohydrate phosphorylation	IDA	J:5824
Biological Process	GO:0046835	carbohydrate phosphorylation	IMP	J:28756
Biological Process	GO:0046835	carbohydrate phosphorylation	IMP	J:29415
Biological Process	GO:0042149	cellular response to glucose starvation	ISO	J:155856
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:155856
Biological Process	GO:0044320	cellular response to leptin stimulus	ISO	J:155856
Biological Process	GO:0051594	detection of glucose	ISO	J:155856
Biological Process	GO:0006003	fructose 2,6-bisphosphate metabolic process	ISO	J:155856
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	ISO	J:155856
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	IMP	J:109919
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	ISO	J:164563
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	ISO	J:155856
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	IBA	J:265628
Biological Process	GO:0006007	glucose catabolic process	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	IMP	J:141688
Biological Process	GO:0042593	glucose homeostasis	ISO	J:155856
Biological Process	GO:0042593	glucose homeostasis	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	IMP	J:43906
Biological Process	GO:0042593	glucose homeostasis	IMP	J:51826
Biological Process	GO:0042593	glucose homeostasis	IMP	J:29415
Biological Process	GO:0042593	glucose homeostasis	IMP	J:30334
Biological Process	GO:0006006	glucose metabolic process	ISO	J:155856
Biological Process	GO:0006006	glucose metabolic process	IBA	J:265628
Biological Process	GO:0006006	glucose metabolic process	IDA	J:8051
Biological Process	GO:0006006	glucose metabolic process	IMP	J:43906
Biological Process	GO:0006006	glucose metabolic process	IMP	J:28756
Biological Process	GO:0006006	glucose metabolic process	IMP	J:29415
Biological Process	GO:0006006	glucose metabolic process	IDA	J:5824
Biological Process	GO:0005978	glycogen biosynthetic process	ISO	J:155856
Biological Process	GO:0006096	glycolytic process	ISO	J:155856
Biological Process	GO:0006096	glycolytic process	IBA	J:265628
Biological Process	GO:0001678	intracellular glucose homeostasis	ISO	J:155856
Biological Process	GO:0001678	intracellular glucose homeostasis	IMP	J:30334
Biological Process	GO:0001678	intracellular glucose homeostasis	IBA	J:265628
Biological Process	GO:0001678	intracellular glucose homeostasis	IMP	J:29255
Biological Process	GO:0055088	lipid homeostasis	ISO	J:155856
Biological Process	GO:0006013	mannose metabolic process	ISO	J:155856
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0006739	NADP metabolic process	IMP	J:115233
Biological Process	GO:0032811	negative regulation of epinephrine secretion	ISO	J:155856
Biological Process	GO:0045721	negative regulation of gluconeogenesis	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	ISO	J:164563
Biological Process	GO:0045821	positive regulation of glycolytic process	ISO	J:155856
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:141688
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:29415
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:155856
Biological Process	GO:0050796	regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0050796	regulation of insulin secretion	IBA	J:265628
Biological Process	GO:0050796	regulation of insulin secretion	IMP	J:38011
Biological Process	GO:0050796	regulation of insulin secretion	IMP	J:30334
Biological Process	GO:0043266	regulation of potassium ion transport	IMP	J:48148
Biological Process	GO:0019932	second-messenger-mediated signaling	ISO	J:155856