GO Annotations Graph

• Symbol: Il12rb2
• Name: interleukin 12 receptor, beta 2
• ID: MGI:1270861

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015026	coreceptor activity	ISO	J:164563
Molecular Function	GO:0019955	cytokine binding	IBA	J:265628
Molecular Function	GO:0004896	cytokine receptor activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:127098
Molecular Function	GO:0019901	protein kinase binding	IPI	J:70821
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:91804
Cellular Component	GO:0042022	interleukin-12 receptor complex	NAS	J:37050
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9006466
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006955	immune response	NAS	J:319975
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:70821
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:70821
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	ISO	J:164563
Biological Process	GO:0051142	positive regulation of NK T cell proliferation	ISO	J:164563
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:65966
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0034097	response to cytokine	IMP	J:70821
Biological Process	GO:0032496	response to lipopolysaccharide	IGI	J:70821
Biological Process	GO:0032609	type II interferon production	IGI	J:70821