GO Annotations Graph

• Symbol: Axin2
• Name: axin 2
• ID: MGI:1270862

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:155856
Molecular Function	GO:0008013	beta-catenin binding	IBA	J:265628
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0070411	I-SMAD binding	IBA	J:265628
Molecular Function	GO:0070411	I-SMAD binding	IPI	J:109361
Molecular Function	GO:0060090	molecular adaptor activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:200483
Molecular Function	GO:0005515	protein binding	IPI	J:205111
Molecular Function	GO:0005515	protein binding	IPI	J:164744
Molecular Function	GO:0005515	protein binding	IPI	J:220301
Molecular Function	GO:0005515	protein binding	IPI	J:47363
Molecular Function	GO:0005515	protein binding	IPI	J:47363
Molecular Function	GO:0005515	protein binding	IPI	J:47363
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	IBA	J:265628
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IBA	J:265628
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IPI	J:109361
Cellular Component	GO:0030877	beta-catenin destruction complex	NAS	J:319997
Cellular Component	GO:0030877	beta-catenin destruction complex	IBA	J:265628
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005813	centrosome	IDA	J:164744
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:179634
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0003180	aortic valve morphogenesis	IMP	J:253368
Biological Process	GO:0030282	bone mineralization	IMP	J:162154
Biological Process	GO:0008219	cell death	ISO	J:155856
Biological Process	GO:0048468	cell development	IBA	J:265628
Biological Process	GO:0008283	cell population proliferation	IMP	J:98523
Biological Process	GO:0008283	cell population proliferation	IMP	J:98523
Biological Process	GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis	IMP	J:162154
Biological Process	GO:0001957	intramembranous ossification	IMP	J:98523
Biological Process	GO:0043570	maintenance of DNA repeat elements	ISO	J:164563
Biological Process	GO:0003183	mitral valve morphogenesis	IMP	J:253368
Biological Process	GO:0048255	mRNA stabilization	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IMP	J:253368
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IMP	J:98523
Biological Process	GO:0033689	negative regulation of osteoblast proliferation	IMP	J:98523
Biological Process	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	ISO	J:155856
Biological Process	GO:0042476	odontogenesis	ISO	J:164563
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:98523
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:98523
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:98523
Biological Process	GO:0033687	osteoblast proliferation	IMP	J:98523
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:164563
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0045600	positive regulation of fat cell differentiation	ISO	J:155856
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:155856
Biological Process	GO:0045860	positive regulation of protein kinase activity	IBA	J:265628
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	J:319997
Biological Process	GO:0008104	protein localization	ISO	J:164563
Biological Process	GO:0070602	regulation of centromeric sister chromatid cohesion	IMP	J:164744
Biological Process	GO:0070602	regulation of centromeric sister chromatid cohesion	ISO	J:164563
Biological Process	GO:0070602	regulation of centromeric sister chromatid cohesion	IBA	J:265628
Biological Process	GO:0061181	regulation of chondrocyte development	IMP	J:162154
Biological Process	GO:1903053	regulation of extracellular matrix organization	IMP	J:253368
Biological Process	GO:0032423	regulation of mismatch repair	ISO	J:164563
Biological Process	GO:0030111	regulation of Wnt signaling pathway	IDA	J:47363
Biological Process	GO:0003139	secondary heart field specification	IGI	J:186421
Biological Process	GO:0001756	somitogenesis	IDA	J:88851
Biological Process	GO:0072089	stem cell proliferation	IMP	J:161359
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000