GO Annotations Graph

• Symbol: Alox12b
• Name: arachidonate 12-lipoxygenase, 12R type
• ID: MGI:1274782

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	IDA	J:102904
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	IMP	J:276497
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	ISO	J:164563
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	IBA	J:265628
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	IDA	J:46510
Molecular Function	GO:0047677	arachidonate 8(R)-lipoxygenase activity	IMP	J:276497
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0005506	iron ion binding	IEA	J:72247
Molecular Function	GO:1990136	linoleate 9S-lipoxygenase activity	IDA	J:102904
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:51421
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IBA	J:265628
Biological Process	GO:0019369	arachidonic acid metabolic process	IDA	J:102904
Biological Process	GO:0019369	arachidonic acid metabolic process	IMP	J:276497
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:164563
Biological Process	GO:0019369	arachidonic acid metabolic process	IMP	J:46510
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:155856
Biological Process	GO:0046513	ceramide biosynthetic process	IMP	J:134709
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:134709
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:174794
Biological Process	GO:0006631	fatty acid metabolic process	IEA	J:60000
Biological Process	GO:0051122	hepoxilin biosynthetic process	ISO	J:155856
Biological Process	GO:0043651	linoleic acid metabolic process	IDA	J:102904
Biological Process	GO:0043651	linoleic acid metabolic process	IBA	J:265628
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0034440	lipid oxidation	IBA	J:265628
Biological Process	GO:0019372	lipoxygenase pathway	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0070257	positive regulation of mucus secretion	ISO	J:164563
Biological Process	GO:0006497	protein lipidation	IMP	J:174794
Biological Process	GO:0006665	sphingolipid metabolic process	ISO	J:164563