GO Annotations Graph

• Symbol: Ep300
• Name: E1A binding protein p300
• ID: MGI:1276116

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016407	acetyltransferase activity	ISO	J:164563
Molecular Function	GO:0016407	acetyltransferase activity	IDA	J:215876
Molecular Function	GO:0016407	acetyltransferase activity	ISS	J:156241
Molecular Function	GO:0016407	acetyltransferase activity	IDA	J:210667
Molecular Function	GO:0016746	acyltransferase activity	ISO	J:164563
Molecular Function	GO:0003823	antigen binding	ISO	J:155856
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0043425	bHLH transcription factor binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:230626
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	IDA	J:188795
Molecular Function	GO:0003682	chromatin binding	IDA	J:199171
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:155856
Molecular Function	GO:0031490	chromatin DNA binding	IBA	J:265628
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:136678
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0003684	damaged DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISS	J:156082
Molecular Function	GO:0003677	DNA binding	IDA	J:95384
Molecular Function	GO:0003677	DNA binding	IDA	J:96189
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:155856
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:219094
Molecular Function	GO:0008047	enzyme activator activity	ISO	J:164563
Molecular Function	GO:0004857	enzyme inhibitor activity	ISO	J:164563
Molecular Function	GO:0004402	histone acetyltransferase activity	ISS	J:156068
Molecular Function	GO:0004402	histone acetyltransferase activity	ISO	J:164563
Molecular Function	GO:0004402	histone acetyltransferase activity	IDA	J:243518
Molecular Function	GO:0004402	histone acetyltransferase activity	ISO	J:155856
Molecular Function	GO:0004402	histone acetyltransferase activity	IBA	J:265628
Molecular Function	GO:0140069	histone butyryltransferase activity	IDA	J:243518
Molecular Function	GO:0140068	histone crotonyltransferase activity	ISO	J:164563
Molecular Function	GO:0044013	histone H2B acetyltransferase activity	ISO	J:164563
Molecular Function	GO:0010484	histone H3 acetyltransferase activity	ISO	J:164563
Molecular Function	GO:0140908	histone H3K122 acetyltransferase activity	ISO	J:164563
Molecular Function	GO:0010485	histone H4 acetyltransferase activity	ISO	J:164563
Molecular Function	GO:0010485	histone H4 acetyltransferase activity	ISS	J:157441
Molecular Function	GO:0120301	histone lactyltransferase activity	ISO	J:164563
Molecular Function	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	ISO	J:155856
Molecular Function	GO:0051059	NF-kappaB binding	ISO	J:155856
Molecular Function	GO:0051059	NF-kappaB binding	ISO	J:164563
Molecular Function	GO:0050681	nuclear androgen receptor binding	ISO	J:164563
Molecular Function	GO:0035259	nuclear glucocorticoid receptor binding	ISO	J:155856
Molecular Function	GO:0016922	nuclear receptor binding	ISO	J:164563
Molecular Function	GO:0002039	p53 binding	ISO	J:155856
Molecular Function	GO:0002039	p53 binding	IPI	J:124168
Molecular Function	GO:0140065	peptide butyryltransferase activity	ISO	J:164563
Molecular Function	GO:0061733	peptide-lysine-N-acetyltransferase activity	IDA	J:272987
Molecular Function	GO:0061733	peptide-lysine-N-acetyltransferase activity	ISO	J:164563
Molecular Function	GO:0042975	peroxisome proliferator activated receptor binding	ISO	J:155856
Molecular Function	GO:0097157	pre-mRNA intronic binding	IDA	J:199171
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:155856
Molecular Function	GO:1990405	protein antigen binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:177244
Molecular Function	GO:0005515	protein binding	IPI	J:222684
Molecular Function	GO:0005515	protein binding	IPI	J:172915
Molecular Function	GO:0005515	protein binding	IPI	J:156082
Molecular Function	GO:0005515	protein binding	IPI	J:172919
Molecular Function	GO:0005515	protein binding	IPI	J:173154
Molecular Function	GO:0005515	protein binding	IPI	J:213900
Molecular Function	GO:0005515	protein binding	IPI	J:214218
Molecular Function	GO:0005515	protein binding	IPI	J:272987
Molecular Function	GO:0005515	protein binding	IPI	J:95385
Molecular Function	GO:0005515	protein binding	IPI	J:224721
Molecular Function	GO:0005515	protein binding	IPI	J:257925
Molecular Function	GO:0005515	protein binding	IPI	J:207820
Molecular Function	GO:0005515	protein binding	IPI	J:148702
Molecular Function	GO:0005515	protein binding	IPI	J:139460
Molecular Function	GO:0005515	protein binding	IPI	J:57302
Molecular Function	GO:0005515	protein binding	ISO	J:120958
Molecular Function	GO:0005515	protein binding	IPI	J:92455
Molecular Function	GO:0005515	protein binding	IPI	J:73196
Molecular Function	GO:0005515	protein binding	IPI	J:140200
Molecular Function	GO:0005515	protein binding	IPI	J:270267
Molecular Function	GO:0005515	protein binding	IPI	J:92455
Molecular Function	GO:0005515	protein binding	IPI	J:57302
Molecular Function	GO:0005515	protein binding	IPI	J:132209
Molecular Function	GO:0005515	protein binding	IPI	J:153063
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0061920	protein propionyltransferase activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:155856
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:142329
Molecular Function	GO:0046332	SMAD binding	ISO	J:155856
Molecular Function	GO:0097677	STAT family protein binding	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	IMP	J:178274
Molecular Function	GO:0003713	transcription coactivator activity	ISS	J:156241
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	ISS	J:156240
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:155856
Molecular Function	GO:0003713	transcription coactivator activity	IBA	J:265628
Molecular Function	GO:0001223	transcription coactivator binding	IPI	J:178274
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:164563
Molecular Function	GO:0003712	transcription coregulator activity	IEA	J:72247
Molecular Function	GO:0001221	transcription coregulator binding	ISO	J:155856
Molecular Function	GO:0001221	transcription coregulator binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0000123	histone acetyltransferase complex	IBA	J:265628
Cellular Component	GO:0000123	histone acetyltransferase complex	IDA	J:57302
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-1368101
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2976706
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-4396387
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-556760
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5617960
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5617990
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619411
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619434
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619441
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663256
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663266
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663291
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663294
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5693628
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9016915
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9017420
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISS	J:156082
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IDA	J:105108
Cellular Component	GO:0032993	protein-DNA complex	ISO	J:155856
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:177244
Cellular Component	GO:0005667	transcription regulator complex	IBA	J:265628
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:80691
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:85949
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISS	J:156082
Biological Process	GO:0030183	B cell differentiation	IMP	J:140200
Biological Process	GO:0002209	behavioral defense response	IMP	J:156907
Biological Process	GO:0051216	cartilage development	NAS	J:177244
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0034644	cellular response to UV	ISO	J:164563
Biological Process	GO:0006338	chromatin remodeling	IMP	J:157441
Biological Process	GO:0007623	circadian rhythm	IDA	J:207820
Biological Process	GO:0060325	face morphogenesis	IMP	J:156907
Biological Process	GO:0045444	fat cell differentiation	IMP	J:224721
Biological Process	GO:0007507	heart development	IMP	J:85949
Biological Process	GO:0016573	histone acetylation	ISO	J:155856
Biological Process	GO:0016573	histone acetylation	IBA	J:265628
Biological Process	GO:0043966	histone H3 acetylation	ISO	J:155856
Biological Process	GO:0018393	internal peptidyl-lysine acetylation	ISO	J:155856
Biological Process	GO:0018393	internal peptidyl-lysine acetylation	ISO	J:164563
Biological Process	GO:0006475	internal protein amino acid acetylation	ISO	J:164563
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO	J:164563
Biological Process	GO:0007611	learning or memory	IMP	J:156907
Biological Process	GO:0030324	lung development	IMP	J:85949
Biological Process	GO:0010742	macrophage derived foam cell differentiation	ISO	J:164563
Biological Process	GO:0035855	megakaryocyte development	IMP	J:140200
Biological Process	GO:0035264	multicellular organism growth	IMP	J:156907
Biological Process	GO:0018076	N-terminal peptidyl-lysine acetylation	ISO	J:164563
Biological Process	GO:0018076	N-terminal peptidyl-lysine acetylation	ISS	J:156241
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0045721	negative regulation of gluconeogenesis	ISO	J:164563
Biological Process	GO:2000629	negative regulation of miRNA metabolic process	ISO	J:155856
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0018394	peptidyl-lysine acetylation	ISO	J:164563
Biological Process	GO:0018394	peptidyl-lysine acetylation	ISO	J:155856
Biological Process	GO:0140067	peptidyl-lysine butyrylation	ISO	J:164563
Biological Process	GO:0140067	peptidyl-lysine butyrylation	IDA	J:243518
Biological Process	GO:0140066	peptidyl-lysine crotonylation	ISO	J:164563
Biological Process	GO:0061921	peptidyl-lysine propionylation	ISO	J:164563
Biological Process	GO:0030220	platelet formation	IGI	J:140200
Biological Process	GO:0030220	platelet formation	IMP	J:140200
Biological Process	GO:0043923	positive regulation by host of viral transcription	ISO	J:164563
Biological Process	GO:0045773	positive regulation of axon extension	ISO	J:155856
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:155856
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	ISO	J:155856
Biological Process	GO:0045793	positive regulation of cell size	ISO	J:155856
Biological Process	GO:1900039	positive regulation of cellular response to hypoxia	ISO	J:155856
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:0043388	positive regulation of DNA binding	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISS	J:64939
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IDA	J:210667
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:177244
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISS	J:156233
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:89650
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:188656
Biological Process	GO:0010560	positive regulation of glycoprotein biosynthetic process	ISO	J:155856
Biological Process	GO:0035066	positive regulation of histone acetylation	ISO	J:155856
Biological Process	GO:0014737	positive regulation of muscle atrophy	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:1901985	positive regulation of protein acetylation	ISO	J:155856
Biological Process	GO:0032092	positive regulation of protein binding	IDA	J:114818
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:155856
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:155856
Biological Process	GO:0045862	positive regulation of proteolysis	ISO	J:155856
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:1905636	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding	ISO	J:164563
Biological Process	GO:0060298	positive regulation of sarcomere organization	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:215876
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:172919
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:111703
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:111703
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:105108
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:92557
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:214105
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:92557
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0045727	positive regulation of translation	ISO	J:155856
Biological Process	GO:0006473	protein acetylation	IDA	J:272987
Biological Process	GO:0006473	protein acetylation	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0043491	protein kinase B signaling	ISO	J:155856
Biological Process	GO:0050821	protein stabilization	IDA	J:215876
Biological Process	GO:0065004	protein-DNA complex assembly	ISO	J:155856
Biological Process	GO:0060765	regulation of androgen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0060177	regulation of angiotensin metabolic process	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006110	regulation of glycolytic process	ISO	J:164563
Biological Process	GO:0010821	regulation of mitochondrion organization	IMP	J:272987
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:80691
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:73196
Biological Process	GO:0090043	regulation of tubulin deacetylation	ISO	J:164563
Biological Process	GO:0051592	response to calcium ion	ISO	J:155856
Biological Process	GO:0071548	response to dexamethasone	ISO	J:155856
Biological Process	GO:0043627	response to estrogen	ISO	J:164563
Biological Process	GO:0009749	response to glucose	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISS	J:156233
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:85950
Biological Process	GO:0001756	somitogenesis	IGI	J:99573
Biological Process	GO:0036268	swimming	IMP	J:156907
Biological Process	GO:0001966	thigmotaxis	IMP	J:156907
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:214105
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:111703
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:111703
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling	ISO	J:164563