GO Annotations Graph

• Symbol: Snca
• Name: synuclein, alpha
• ID: MGI:1277151

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0043014	alpha-tubulin binding	ISO	J:164563
Molecular Function	GO:0050544	arachidonic acid binding	IDA	J:109641
Molecular Function	GO:0048487	beta-tubulin binding	ISO	J:155856
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005507	copper ion binding	ISO	J:164563
Molecular Function	GO:1903136	cuprous ion binding	ISO	J:164563
Molecular Function	GO:1903136	cuprous ion binding	IBA	J:265628
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO	J:164563
Molecular Function	GO:0070840	dynein complex binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0008198	ferrous iron binding	ISO	J:164563
Molecular Function	GO:0042393	histone binding	IDA	J:154831
Molecular Function	GO:0042393	histone binding	ISO	J:164563
Molecular Function	GO:0030544	Hsp70 protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IDA	J:64149
Molecular Function	GO:0019894	kinesin binding	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	ISO	J:164563
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008017	microtubule binding	ISO	J:155856
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	ISO	J:164563
Molecular Function	GO:0043274	phospholipase binding	ISO	J:155856
Molecular Function	GO:0005543	phospholipid binding	ISO	J:164563
Molecular Function	GO:0005543	phospholipid binding	ISO	J:155856
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:210101
Molecular Function	GO:0005515	protein binding	IPI	J:136786
Molecular Function	GO:0005515	protein binding	IPI	J:201939
Molecular Function	GO:0005515	protein binding	IPI	J:232550
Molecular Function	GO:0005515	protein binding	IPI	J:215464
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0000149	SNARE binding	ISO	J:164563
Molecular Function	GO:0048156	tau protein binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:164563
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0043679	axon terminus	IDA	J:136786
Cellular Component	GO:0043679	axon terminus	IBA	J:265628
Cellular Component	GO:0005938	cell cortex	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:160542
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:122473
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	ISO	J:155856
Cellular Component	GO:0005856	cytoskeleton	IDA	J:129746
Cellular Component	GO:0005829	cytosol	IDA	J:150319
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:164563
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0016234	inclusion body	IDA	J:212805
Cellular Component	GO:0016234	inclusion body	ISO	J:164563
Cellular Component	GO:0016234	inclusion body	IDA	J:202009
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:155856
Cellular Component	GO:0005758	mitochondrial intermembrane space	ISO	J:155856
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:155856
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IMP	J:225806
Cellular Component	GO:0043025	neuronal cell body	IBA	J:265628
Cellular Component	GO:0005640	nuclear outer membrane	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:154831
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:216463
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:122473
Cellular Component	GO:0031092	platelet alpha granule membrane	ISO	J:164563
Cellular Component	GO:0098793	presynapse	IDA	J:215304
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0005840	ribosome	ISO	J:155856
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0099512	supramolecular fiber	ISO	J:164563
Cellular Component	GO:0045202	synapse	IDA	J:215304
Cellular Component	GO:0045202	synapse	IDA	J:64205
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0030672	synaptic vesicle membrane	IDA	J:251123
Cellular Component	GO:0030672	synaptic vesicle membrane	IEP	J:251123
Cellular Component	GO:0030672	synaptic vesicle membrane	IDA	J:251123
Cellular Component	GO:0030672	synaptic vesicle membrane	IDA	J:251123
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0008344	adult locomotory behavior	IGI	J:132938
Biological Process	GO:1990000	amyloid fibril formation	ISO	J:164563
Biological Process	GO:0048148	behavioral response to cocaine	ISO	J:155856
Biological Process	GO:0071280	cellular response to copper ion	ISO	J:164563
Biological Process	GO:0034599	cellular response to oxidative stress	IMP	J:106226
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0007268	chemical synaptic transmission	IGI	J:167549
Biological Process	GO:0007268	chemical synaptic transmission	IGI	J:167549
Biological Process	GO:0042416	dopamine biosynthetic process	IMP	J:60151
Biological Process	GO:0042417	dopamine metabolic process	IGI	J:93544
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:126092
Biological Process	GO:0006631	fatty acid metabolic process	IMP	J:122525
Biological Process	GO:0006631	fatty acid metabolic process	IMP	J:118570
Biological Process	GO:0051179	localization	ISO	J:164563
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:134812
Biological Process	GO:0061024	membrane organization	IMP	J:118570
Biological Process	GO:0001774	microglial cell activation	IMP	J:113229
Biological Process	GO:0042775	mitochondrial ATP synthesis coupled electron transport	IMP	J:102361
Biological Process	GO:0007006	mitochondrial membrane organization	IMP	J:102361
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:1904715	negative regulation of chaperone-mediated autophagy	ISO	J:164563
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0045963	negative regulation of dopamine metabolic process	ISO	J:155856
Biological Process	GO:0051585	negative regulation of dopamine uptake involved in synaptic transmission	ISO	J:164563
Biological Process	GO:0045920	negative regulation of exocytosis	ISO	J:164563
Biological Process	GO:0035067	negative regulation of histone acetylation	ISO	J:164563
Biological Process	GO:0031115	negative regulation of microtubule polymerization	ISO	J:164563
Biological Process	GO:0032769	negative regulation of monooxygenase activity	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IGI	J:115193
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:164563
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0051622	negative regulation of norepinephrine uptake	ISO	J:164563
Biological Process	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0051612	negative regulation of serotonin uptake	ISO	J:164563
Biological Process	GO:0070495	negative regulation of thrombin-activated receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032410	negative regulation of transporter activity	ISO	J:164563
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:101289
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:115193
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:101289
Biological Process	GO:0007269	neurotransmitter secretion	IDA	J:94390
Biological Process	GO:0007269	neurotransmitter secretion	IDA	J:94390
Biological Process	GO:0006638	neutral lipid metabolic process	IMP	J:122525
Biological Process	GO:0006644	phospholipid metabolic process	IMP	J:102361
Biological Process	GO:0006644	phospholipid metabolic process	IMP	J:99690
Biological Process	GO:0006644	phospholipid metabolic process	IMP	J:109641
Biological Process	GO:0045807	positive regulation of endocytosis	ISO	J:164563
Biological Process	GO:0045921	positive regulation of exocytosis	ISO	J:164563
Biological Process	GO:1903284	positive regulation of glutathione peroxidase activity	ISO	J:164563
Biological Process	GO:1903285	positive regulation of hydrogen peroxide catabolic process	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0060732	positive regulation of inositol phosphate biosynthetic process	ISO	J:164563
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:164563
Biological Process	GO:0001956	positive regulation of neurotransmitter secretion	IDA	J:94390
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IMP	J:168706
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0001921	positive regulation of receptor recycling	ISO	J:164563
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0035543	positive regulation of SNARE complex assembly	ISO	J:164563
Biological Process	GO:0050806	positive regulation of synaptic transmission	IMP	J:101275
Biological Process	GO:0051259	protein complex oligomerization	IDA	J:216463
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0051262	protein tetramerization	ISO	J:164563
Biological Process	GO:0031623	receptor internalization	ISO	J:164563
Biological Process	GO:0050812	regulation of acyl-CoA biosynthetic process	IMP	J:109461
Biological Process	GO:0050812	regulation of acyl-CoA biosynthetic process	IDA	J:109641
Biological Process	GO:0014059	regulation of dopamine secretion	TAS	J:212791
Biological Process	GO:0014059	regulation of dopamine secretion	IGI	J:132938
Biological Process	GO:0014048	regulation of glutamate secretion	IMP	J:134812
Biological Process	GO:0040012	regulation of locomotion	IMP	J:60151
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	IMP	J:94390
Biological Process	GO:0043030	regulation of macrophage activation	IMP	J:113229
Biological Process	GO:1901214	regulation of neuron death	ISO	J:155856
Biological Process	GO:1901214	regulation of neuron death	IBA	J:265628
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	IMP	J:126092
Biological Process	GO:0046928	regulation of neurotransmitter secretion	IGI	J:132938
Biological Process	GO:0046928	regulation of neurotransmitter secretion	IMP	J:60151
Biological Process	GO:0046928	regulation of neurotransmitter secretion	IMP	J:94390
Biological Process	GO:0046928	regulation of neurotransmitter secretion	IMP	J:79784
Biological Process	GO:0051621	regulation of norepinephrine uptake	ISO	J:164563
Biological Process	GO:0010517	regulation of phospholipase activity	ISO	J:164563
Biological Process	GO:1905606	regulation of presynapse assembly	ISO	J:164563
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	IMP	J:213707
Biological Process	GO:0022898	regulation of transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0070555	response to interleukin-1	ISO	J:164563
Biological Process	GO:0010040	response to iron(II) ion	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0032026	response to magnesium ion	ISO	J:164563
Biological Process	GO:0034341	response to type II interferon	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:60151
Biological Process	GO:0035493	SNARE complex assembly	IDA	J:216463
Biological Process	GO:0035493	SNARE complex assembly	ISO	J:164563
Biological Process	GO:0050808	synapse organization	IBA	J:265628
Biological Process	GO:0050808	synapse organization	IGI	J:167549
Biological Process	GO:0050808	synapse organization	IGI	J:167549
Biological Process	GO:0001963	synaptic transmission, dopaminergic	IMP	J:79784
Biological Process	GO:0001963	synaptic transmission, dopaminergic	IMP	J:60151
Biological Process	GO:0048488	synaptic vesicle endocytosis	IMP	J:150319
Biological Process	GO:0048488	synaptic vesicle endocytosis	IBA	J:265628
Biological Process	GO:0048488	synaptic vesicle endocytosis	IDA	J:215304
Biological Process	GO:0048488	synaptic vesicle endocytosis	IMP	J:215304
Biological Process	GO:0048488	synaptic vesicle endocytosis	IDA	J:215304
Biological Process	GO:0048488	synaptic vesicle endocytosis	IDA	J:215304
Biological Process	GO:0048488	synaptic vesicle endocytosis	IMP	J:215304
Biological Process	GO:0016079	synaptic vesicle exocytosis	ISO	J:164563
Biological Process	GO:0016082	synaptic vesicle priming	ISO	J:164563
Biological Process	GO:0048489	synaptic vesicle transport	IMP	J:79784