GO Annotations Graph

• Symbol: Sp3
• Name: trans-acting transcription factor 3
• ID: MGI:1277166

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:93510
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:157160
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:95047
Molecular Function	GO:0003677	DNA binding	ISS	J:97532
Molecular Function	GO:0003677	DNA binding	IDA	J:88707
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TAS	J:94649
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:172987
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:94649
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:306580
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:126723
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:89274
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:172987
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:155856
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:94649
Cellular Component	GO:0005634	nucleus	IDA	J:99289
Cellular Component	GO:0032993	protein-DNA complex	ISO	J:155856
Cellular Component	GO:0017053	transcription repressor complex	IDA	J:172987
Cellular Component	GO:0017053	transcription repressor complex	ISO	J:155856
Biological Process	GO:0030183	B cell differentiation	IMP	J:84837
Biological Process	GO:0060216	definitive hemopoiesis	IGI	J:123073
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	IGI	J:123073
Biological Process	GO:0001892	embryonic placenta development	IGI	J:123073
Biological Process	GO:0001892	embryonic placenta development	IGI	J:123073
Biological Process	GO:0060136	embryonic process involved in female pregnancy	IGI	J:123073
Biological Process	GO:0048706	embryonic skeletal system development	IGI	J:123073
Biological Process	GO:0043353	enucleate erythrocyte differentiation	IGI	J:123073
Biological Process	GO:0030218	erythrocyte differentiation	IMP	J:84837
Biological Process	GO:0030851	granulocyte differentiation	IMP	J:84837
Biological Process	GO:0001701	in utero embryonic development	IGI	J:123073
Biological Process	GO:0001889	liver development	IGI	J:123073
Biological Process	GO:0030324	lung development	IGI	J:123073
Biological Process	GO:0030219	megakaryocyte differentiation	IGI	J:123073
Biological Process	GO:0030224	monocyte differentiation	IMP	J:84837
Biological Process	GO:0002318	myeloid progenitor cell differentiation	IGI	J:123073
Biological Process	GO:0001779	natural killer cell differentiation	IMP	J:84837
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:172987
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0001503	ossification	IGI	J:123073
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	TAS	J:94649
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0030217	T cell differentiation	IMP	J:84837
Biological Process	GO:0001829	trophectodermal cell differentiation	IGI	J:123073
Biological Process	GO:0001829	trophectodermal cell differentiation	IGI	J:123073