Tyrobp GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Tyrobp
TYRO protein tyrosine kinase binding protein
MGI:1277211

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019209	kinase activator activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:73938
Molecular Function	GO:0005515	protein binding	IPI	J:49203
Molecular Function	GO:0005515	protein binding	IPI	J:147155
Molecular Function	GO:0005515	protein binding	IPI	J:116120
Molecular Function	GO:0005515	protein binding	IPI	J:219772
Molecular Function	GO:0005515	protein binding	IPI	J:144335
Molecular Function	GO:0005515	protein binding	IPI	J:84951
Molecular Function	GO:0005515	protein binding	IPI	J:197348
Molecular Function	GO:0005515	protein binding	IPI	J:193006
Molecular Function	GO:0005515	protein binding	IPI	J:219772
Molecular Function	GO:0005515	protein binding	IPI	J:124243
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:260524
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:49203
Cellular Component	GO:0009986	cell surface	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2326808
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2395436
Biological Process	GO:0030036	actin cytoskeleton organization	IMP	J:139490
Biological Process	GO:0043277	apoptotic cell clearance	IMP	J:96626
Biological Process	GO:0097190	apoptotic signaling pathway	IDA	J:140167
Biological Process	GO:0030900	forebrain development	IDA	J:140167
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0007229	integrin-mediated signaling pathway	IMP	J:116120
Biological Process	GO:0002281	macrophage activation involved in immune response	IMP	J:116120
Biological Process	GO:0002282	microglial cell activation involved in immune response	IMP	J:221150
Biological Process	GO:0002282	microglial cell activation involved in immune response	IMP	J:221150
Biological Process	GO:0002282	microglial cell activation involved in immune response	IBA	J:265628
Biological Process	GO:0002274	myeloid leukocyte activation	ISO	J:164563
Biological Process	GO:0030889	negative regulation of B cell proliferation	ISO	J:164563
Biological Process	GO:0030889	negative regulation of B cell proliferation	IMP	J:177613
Biological Process	GO:0030889	negative regulation of B cell proliferation	IBA	J:265628
Biological Process	GO:0032693	negative regulation of interleukin-10 production	IMP	J:221150
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	IMP	J:96801
Biological Process	GO:0032911	negative regulation of transforming growth factor beta1 production	IMP	J:221150
Biological Process	GO:0032911	negative regulation of transforming growth factor beta1 production	IBA	J:265628
Biological Process	GO:0032480	negative regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0002283	neutrophil activation involved in immune response	IMP	J:116120
Biological Process	GO:0002283	neutrophil activation involved in immune response	IBA	J:265628
Biological Process	GO:0030316	osteoclast differentiation	IGI	J:178250
Biological Process	GO:0030316	osteoclast differentiation	ISO	J:178250
Biological Process	GO:0030316	osteoclast differentiation	IDA	J:178250
Biological Process	GO:0030316	osteoclast differentiation	IMP	J:178250
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:221150
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:221150
Biological Process	GO:0110090	positive regulation of hippocampal neuron apoptotic process	IDA	J:140167
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:221150
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:221150
Biological Process	GO:0034241	positive regulation of macrophage fusion	ISO	J:164563
Biological Process	GO:0034241	positive regulation of macrophage fusion	IMP	J:258167
Biological Process	GO:0034241	positive regulation of macrophage fusion	IBA	J:265628
Biological Process	GO:1904151	positive regulation of microglial cell mediated cytotoxicity	IMP	J:140167
Biological Process	GO:1904151	positive regulation of microglial cell mediated cytotoxicity	IBA	J:265628
Biological Process	GO:0032816	positive regulation of natural killer cell activation	IDA	J:49203
Biological Process	GO:0032816	positive regulation of natural killer cell activation	IBA	J:265628
Biological Process	GO:1901216	positive regulation of neuron death	IMP	J:221150
Biological Process	GO:2001206	positive regulation of osteoclast development	IMP	J:111212
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	ISO	J:164563
Biological Process	GO:1902685	positive regulation of receptor localization to synapse	IMP	J:96801
Biological Process	GO:0032930	positive regulation of superoxide anion generation	IDA	J:140167
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:221150
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:2001204	regulation of osteoclast development	IGI	J:193006
Biological Process	GO:0048678	response to axon injury	IMP	J:221150
Biological Process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0002222	stimulatory killer cell immunoglobulin-like receptor signaling pathway	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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