GO Annotations Graph

• Symbol: Dlg4
• Name: discs large MAGUK scaffold protein 4
• ID: MGI:1277959

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0033130	acetylcholine receptor binding	ISO	J:155856
Molecular Function	GO:0031697	beta-1 adrenergic receptor binding	ISO	J:155856
Molecular Function	GO:0031698	beta-2 adrenergic receptor binding	ISO	J:155856
Molecular Function	GO:0031748	D1 dopamine receptor binding	ISO	J:155856
Molecular Function	GO:0005109	frizzled binding	ISO	J:155856
Molecular Function	GO:0035254	glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0019865	immunoglobulin binding	ISO	J:155856
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	IPI	J:150922
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0019900	kinase binding	ISO	J:168713
Molecular Function	GO:0019894	kinesin binding	ISO	J:155856
Molecular Function	GO:0042043	neurexin family protein binding	NAS	J:113666
Molecular Function	GO:0097109	neuroligin family protein binding	ISO	J:155856
Molecular Function	GO:0031812	P2Y1 nucleotide receptor binding	ISO	J:155856
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:145953
Molecular Function	GO:0005515	protein binding	IPI	J:113901
Molecular Function	GO:0005515	protein binding	IPI	J:113901
Molecular Function	GO:0005515	protein binding	IPI	J:116426
Molecular Function	GO:0005515	protein binding	IPI	J:145953
Molecular Function	GO:0005515	protein binding	IPI	J:149521
Molecular Function	GO:0005515	protein binding	IPI	J:202713
Molecular Function	GO:0005515	protein binding	IPI	J:127744
Molecular Function	GO:0005515	protein binding	IPI	J:127744
Molecular Function	GO:0005515	protein binding	IPI	J:312331
Molecular Function	GO:0005515	protein binding	IPI	J:105764
Molecular Function	GO:0005515	protein binding	IPI	J:119025
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0005515	protein binding	IPI	J:146779
Molecular Function	GO:0005515	protein binding	IPI	J:174472
Molecular Function	GO:0005515	protein binding	IPI	J:286227
Molecular Function	GO:0005515	protein binding	IPI	J:175149
Molecular Function	GO:0005515	protein binding	IPI	J:63100
Molecular Function	GO:0005515	protein binding	IPI	J:292854
Molecular Function	GO:0005515	protein binding	IPI	J:181943
Molecular Function	GO:0005515	protein binding	IPI	J:200324
Molecular Function	GO:0005515	protein binding	IPI	J:161179
Molecular Function	GO:0005515	protein binding	IPI	J:264502
Molecular Function	GO:0005515	protein binding	IPI	J:152628
Molecular Function	GO:0005515	protein binding	IPI	J:226018
Molecular Function	GO:0005515	protein binding	IPI	J:194528
Molecular Function	GO:0005515	protein binding	IPI	J:227842
Molecular Function	GO:0005515	protein binding	IPI	J:241916
Molecular Function	GO:0005515	protein binding	IPI	J:225474
Molecular Function	GO:0005515	protein binding	IPI	J:255015
Molecular Function	GO:0005515	protein binding	IPI	J:241916
Molecular Function	GO:0005515	protein binding	IPI	J:263407
Molecular Function	GO:0005515	protein binding	IPI	J:236346
Molecular Function	GO:0005515	protein binding	IPI	J:193326
Molecular Function	GO:0005515	protein binding	IPI	J:194528
Molecular Function	GO:0005515	protein binding	IPI	J:193326
Molecular Function	GO:0005515	protein binding	IPI	J:162088
Molecular Function	GO:0005515	protein binding	IPI	J:116426
Molecular Function	GO:0005515	protein binding	IPI	J:200324
Molecular Function	GO:0005515	protein binding	IPI	J:200294
Molecular Function	GO:0005515	protein binding	IPI	J:230557
Molecular Function	GO:0005515	protein binding	IPI	J:112964
Molecular Function	GO:0005515	protein binding	IPI	J:100200
Molecular Function	GO:0005515	protein binding	IPI	J:90197
Molecular Function	GO:0005515	protein binding	IPI	J:212850
Molecular Function	GO:0005515	protein binding	IPI	J:99780
Molecular Function	GO:0005515	protein binding	IPI	J:111553
Molecular Function	GO:0005515	protein binding	IPI	J:48437
Molecular Function	GO:0005515	protein binding	IPI	J:48437
Molecular Function	GO:0005515	protein binding	IPI	J:251210
Molecular Function	GO:0005515	protein binding	IPI	J:112964
Molecular Function	GO:0005515	protein binding	IPI	J:99780
Molecular Function	GO:0005515	protein binding	IPI	J:48437
Molecular Function	GO:0005515	protein binding	IPI	J:100200
Molecular Function	GO:0005515	protein binding	IPI	J:48437
Molecular Function	GO:0005515	protein binding	IPI	J:113153
Molecular Function	GO:0005515	protein binding	IPI	J:99780
Molecular Function	GO:0005515	protein binding	IPI	J:113153
Molecular Function	GO:0005515	protein binding	IPI	J:75815
Molecular Function	GO:0005515	protein binding	IPI	J:150806
Molecular Function	GO:0005515	protein binding	IPI	J:45446
Molecular Function	GO:0005515	protein binding	IPI	J:70687
Molecular Function	GO:0005515	protein binding	IPI	J:95556
Molecular Function	GO:0005515	protein binding	IPI	J:207532
Molecular Function	GO:0005515	protein binding	IPI	J:48437
Molecular Function	GO:0005515	protein binding	IPI	J:112964
Molecular Function	GO:0005515	protein binding	IPI	J:124046
Molecular Function	GO:0005515	protein binding	IPI	J:100200
Molecular Function	GO:0005515	protein binding	IPI	J:113153
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	IPI	J:108736
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0098919	structural constituent of postsynaptic density	ISO	J:155856
Molecular Function	GO:0005198	structural molecule activity	NAS	J:89778
Cellular Component	GO:0032281	AMPA glutamate receptor complex	IDA	J:100200
Cellular Component	GO:0032281	AMPA glutamate receptor complex	IDA	J:188364
Cellular Component	GO:0030054	cell junction	IDA	J:178643
Cellular Component	GO:0030054	cell junction	IDA	J:178643
Cellular Component	GO:0071944	cell periphery	IDA	J:112964
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	ISO	J:155856
Cellular Component	GO:0044300	cerebellar mossy fiber	IDA	J:201692
Cellular Component	GO:0030863	cortical cytoskeleton	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:70687
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IDA	J:197846
Cellular Component	GO:0032839	dendrite cytoplasm	ISO	J:155856
Cellular Component	GO:0044307	dendritic branch	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	IDA	J:206832
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:111556
Cellular Component	GO:0060076	excitatory synapse	IDA	J:132277
Cellular Component	GO:0060076	excitatory synapse	ISO	J:155856
Cellular Component	GO:0060076	excitatory synapse	IDA	J:294276
Cellular Component	GO:0060076	excitatory synapse	IDA	J:113153
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:122983
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:122983
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:122983
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:122983
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:122983
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:122983
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:122983
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:122983
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:122983
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:122983
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:122983
Cellular Component	GO:0044224	juxtaparanode region of axon	ISO	J:155856
Cellular Component	GO:0044224	juxtaparanode region of axon	ISO	J:73065
Cellular Component	GO:0044224	juxtaparanode region of axon	IDA	J:143878
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:99780
Cellular Component	GO:0016020	membrane	IDA	J:90197
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0031594	neuromuscular junction	IBA	J:265628
Cellular Component	GO:0043005	neuron projection	IBA	J:265628
Cellular Component	GO:0044306	neuron projection terminus	IDA	J:77234
Cellular Component	GO:0044309	neuron spine	IDA	J:108736
Cellular Component	GO:0044309	neuron spine	IDA	J:113153
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-443767
Cellular Component	GO:0005886	plasma membrane	IDA	J:70687
Cellular Component	GO:0005886	plasma membrane	IDA	J:108232
Cellular Component	GO:0005886	plasma membrane	IDA	J:108232
Cellular Component	GO:0098794	postsynapse	IDA	J:301846
Cellular Component	GO:0098794	postsynapse	IDA	J:240496
Cellular Component	GO:0014069	postsynaptic density	IDA	J:237681
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:260353
Cellular Component	GO:0014069	postsynaptic density	IDA	J:114917
Cellular Component	GO:0014069	postsynaptic density	IDA	J:116055
Cellular Component	GO:0014069	postsynaptic density	ISO	J:211830
Cellular Component	GO:0014069	postsynaptic density	IDA	J:201826
Cellular Component	GO:0014069	postsynaptic density	IDA	J:201692
Cellular Component	GO:0014069	postsynaptic density	IDA	J:207532
Cellular Component	GO:0014069	postsynaptic density	IDA	J:96798
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0014069	postsynaptic density	IDA	J:179583
Cellular Component	GO:0014069	postsynaptic density	IDA	J:92648
Cellular Component	GO:0014069	postsynaptic density	ISO	J:120748
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:152455
Cellular Component	GO:0098839	postsynaptic density membrane	IBA	J:265628
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:164563
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:150922
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:73065
Cellular Component	GO:1990635	proximal dendrite	ISO	J:155856
Cellular Component	GO:0045202	synapse	IMP	J:194528
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:164563
Cellular Component	GO:0045202	synapse	IDA	J:201575
Cellular Component	GO:0045202	synapse	ISO	J:96464
Cellular Component	GO:0045202	synapse	IDA	J:86623
Cellular Component	GO:0045202	synapse	ISO	J:73065
Cellular Component	GO:0045202	synapse	IDA	J:111190
Cellular Component	GO:0045202	synapse	IDA	J:251210
Cellular Component	GO:0045202	synapse	ISO	J:95877
Cellular Component	GO:0045202	synapse	IDA	J:86846
Cellular Component	GO:0045202	synapse	IDA	J:90137
Cellular Component	GO:0045202	synapse	IDA	J:201692
Cellular Component	GO:0045202	synapse	IDA	J:85759
Cellular Component	GO:0045202	synapse	IDA	J:132267
Cellular Component	GO:0097060	synaptic membrane	ISO	J:155856
Cellular Component	GO:0097060	synaptic membrane	IDA	J:196653
Cellular Component	GO:0008021	synaptic vesicle	IDA	J:108232
Biological Process	GO:0097113	AMPA glutamate receptor clustering	ISO	J:155856
Biological Process	GO:0097113	AMPA glutamate receptor clustering	IBA	J:265628
Biological Process	GO:0035865	cellular response to potassium ion	IDA	J:227842
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0060997	dendritic spine morphogenesis	ISO	J:155856
Biological Process	GO:0060997	dendritic spine morphogenesis	IDA	J:175436
Biological Process	GO:0097061	dendritic spine organization	ISO	J:155856
Biological Process	GO:0045184	establishment of protein localization	ISO	J:164563
Biological Process	GO:0007626	locomotory behavior	NAS	J:89778
Biological Process	GO:0035641	locomotory exploration behavior	IMP	J:175436
Biological Process	GO:0002091	negative regulation of receptor internalization	ISO	J:155856
Biological Process	GO:0050885	neuromuscular process controlling balance	IMP	J:175436
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IMP	J:122983
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:122983
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:122983
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:122983
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:122983
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IEP	J:122983
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IMP	J:122983
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:122983
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:122983
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:122983
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IMP	J:122983
Biological Process	GO:1904719	positive regulation of AMPA glutamate receptor clustering	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	ISO	J:155856
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0150012	positive regulation of neuron projection arborization	ISO	J:155856
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	ISO	J:155856
Biological Process	GO:0050806	positive regulation of synaptic transmission	ISO	J:155856
Biological Process	GO:0098970	postsynaptic neurotransmitter receptor diffusion trapping	ISO	J:155856
Biological Process	GO:0098970	postsynaptic neurotransmitter receptor diffusion trapping	IBA	J:265628
Biological Process	GO:0035418	protein localization to synapse	ISO	J:155856
Biological Process	GO:0035418	protein localization to synapse	ISO	J:164563
Biological Process	GO:0035418	protein localization to synapse	IDA	J:99780
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0097120	receptor localization to synapse	ISO	J:155856
Biological Process	GO:2000821	regulation of grooming behavior	IMP	J:175436
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	IGI	J:98903
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	ISO	J:155856
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	NAS	J:89778
Biological Process	GO:2000310	regulation of NMDA receptor activity	ISO	J:155856
Biological Process	GO:0042220	response to cocaine	NAS	J:89778
Biological Process	GO:0035176	social behavior	IMP	J:175436
Biological Process	GO:0016188	synaptic vesicle maturation	IGI	J:94875
Biological Process	GO:0016188	synaptic vesicle maturation	IDA	J:94875
Biological Process	GO:0071625	vocalization behavior	IMP	J:175436