GO Annotations Graph

• Symbol: Plec
• Name: plectin
• ID: MGI:1277961

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IDA	J:58810
Molecular Function	GO:0051015	actin filament binding	IDA	J:50970
Molecular Function	GO:0030506	ankyrin binding	ISO	J:164563
Molecular Function	GO:0030506	ankyrin binding	ISO	J:155856
Molecular Function	GO:0030506	ankyrin binding	IBA	J:265628
Molecular Function	GO:0008092	cytoskeletal protein binding	ISO	J:155856
Molecular Function	GO:0002162	dystroglycan binding	IDA	J:199446
Molecular Function	GO:0005515	protein binding	IPI	J:322687
Molecular Function	GO:0005515	protein binding	IPI	J:263469
Molecular Function	GO:0005515	protein binding	IPI	J:247425
Molecular Function	GO:0005515	protein binding	IPI	J:140957
Molecular Function	GO:0005515	protein binding	IPI	J:115898
Molecular Function	GO:0005515	protein binding	IPI	J:134710
Molecular Function	GO:0005515	protein binding	IPI	J:78852
Molecular Function	GO:0005515	protein binding	IPI	J:108933
Molecular Function	GO:0005515	protein binding	IPI	J:156784
Molecular Function	GO:0005515	protein binding	IPI	J:134710
Molecular Function	GO:0005515	protein binding	IPI	J:134710
Molecular Function	GO:0043621	protein self-association	IDA	J:179812
Molecular Function	GO:0005200	structural constituent of cytoskeleton	ISO	J:155856
Molecular Function	GO:0005200	structural constituent of cytoskeleton	IBA	J:265628
Molecular Function	GO:0008307	structural constituent of muscle	ISO	J:164563
Molecular Function	GO:0008307	structural constituent of muscle	IBA	J:265628
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0030424	axon	IDA	J:155511
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:155856
Cellular Component	GO:0005903	brush border	IDA	J:219622
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0071944	cell periphery	IDA	J:59000
Cellular Component	GO:0043292	contractile fiber	IDA	J:87935
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:199446
Cellular Component	GO:0005856	cytoskeleton	IEA	J:72247
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	IDA	J:155511
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	IBA	J:265628
Cellular Component	GO:0030056	hemidesmosome	ISO	J:164563
Cellular Component	GO:0030056	hemidesmosome	IBA	J:265628
Cellular Component	GO:0030056	hemidesmosome	IDA	J:179812
Cellular Component	GO:0005882	intermediate filament	IBA	J:265628
Cellular Component	GO:0045111	intermediate filament cytoskeleton	ISO	J:164563
Cellular Component	GO:0005741	mitochondrial outer membrane	IMP	J:137222
Cellular Component	GO:0043209	myelin sheath	IDA	J:155511
Cellular Component	GO:0030016	myofibril	IDA	J:223926
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IBA	J:265628
Cellular Component	GO:0042383	sarcolemma	ISO	J:164563
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	IBA	J:265628
Cellular Component	GO:0042383	sarcolemma	IDA	J:134710
Cellular Component	GO:0016528	sarcoplasm	ISO	J:155856
Cellular Component	GO:0030018	Z disc	IDA	J:134710
Biological Process	GO:0030036	actin cytoskeleton organization	IMP	J:50970
Biological Process	GO:0030036	actin cytoskeleton organization	IMP	J:104701
Biological Process	GO:0007015	actin filament organization	IMP	J:234446
Biological Process	GO:2000689	actomyosin contractile ring assembly actin filament organization	IMP	J:234446
Biological Process	GO:0034332	adherens junction organization	IMP	J:234446
Biological Process	GO:0055013	cardiac muscle cell development	IMP	J:59000
Biological Process	GO:0000902	cell morphogenesis	IMP	J:50970
Biological Process	GO:0048870	cell motility	IMP	J:50970
Biological Process	GO:0031668	cellular response to extracellular stimulus	IMP	J:50970
Biological Process	GO:0071498	cellular response to fluid shear stress	IMP	J:50970
Biological Process	GO:0071464	cellular response to hydrostatic pressure	IMP	J:218779
Biological Process	GO:0071260	cellular response to mechanical stimulus	IMP	J:234446
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:124213
Biological Process	GO:0010761	fibroblast migration	IMP	J:104701
Biological Process	GO:0010467	gene expression	IMP	J:156784
Biological Process	GO:0010467	gene expression	IMP	J:209429
Biological Process	GO:0031581	hemidesmosome assembly	ISO	J:164563
Biological Process	GO:0031581	hemidesmosome assembly	IBA	J:265628
Biological Process	GO:0045104	intermediate filament cytoskeleton organization	IBA	J:265628
Biological Process	GO:0045104	intermediate filament cytoskeleton organization	IMP	J:199446
Biological Process	GO:0045109	intermediate filament organization	IMP	J:209429
Biological Process	GO:0045109	intermediate filament organization	IMP	J:137222
Biological Process	GO:0045109	intermediate filament organization	IMP	J:137067
Biological Process	GO:0045109	intermediate filament organization	IMP	J:226972
Biological Process	GO:0045109	intermediate filament organization	IMP	J:234446
Biological Process	GO:0003334	keratinocyte development	IMP	J:124213
Biological Process	GO:0030216	keratinocyte differentiation	IMP	J:218779
Biological Process	GO:0002522	leukocyte migration involved in immune response	IMP	J:104701
Biological Process	GO:0070584	mitochondrion morphogenesis	IMP	J:137222
Biological Process	GO:0007005	mitochondrion organization	IMP	J:137222
Biological Process	GO:0007005	mitochondrion organization	IMP	J:137067
Biological Process	GO:0035264	multicellular organism growth	IMP	J:124213
Biological Process	GO:0022011	myelination in peripheral nervous system	IMP	J:155511
Biological Process	GO:0022011	myelination in peripheral nervous system	IMP	J:155511
Biological Process	GO:0045445	myoblast differentiation	IMP	J:218779
Biological Process	GO:0006469	negative regulation of protein kinase activity	IMP	J:78852
Biological Process	GO:0006997	nucleus organization	IMP	J:226972
Biological Process	GO:0032287	peripheral nervous system myelin maintenance	IMP	J:199446
Biological Process	GO:0008104	protein localization	IMP	J:108933
Biological Process	GO:0043933	protein-containing complex organization	IMP	J:108933
Biological Process	GO:2000983	regulation of ATP citrate synthase activity	IMP	J:223926
Biological Process	GO:0043114	regulation of vascular permeability	IMP	J:234446
Biological Process	GO:0022904	respiratory electron transport chain	IMP	J:223926
Biological Process	GO:0032094	response to food	IMP	J:124213
Biological Process	GO:0007584	response to nutrient	ISO	J:155856
Biological Process	GO:0045214	sarcomere organization	IMP	J:209429
Biological Process	GO:0048741	skeletal muscle fiber development	IMP	J:209429
Biological Process	GO:0048741	skeletal muscle fiber development	IMP	J:137067
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:59000
Biological Process	GO:0014866	skeletal myofibril assembly	IMP	J:209429
Biological Process	GO:0043588	skin development	IMP	J:124213
Biological Process	GO:0043588	skin development	IMP	J:59000
Biological Process	GO:0010818	T cell chemotaxis	IMP	J:104701
Biological Process	GO:0120193	tight junction organization	IMP	J:234446
Biological Process	GO:0019226	transmission of nerve impulse	IMP	J:155511
Biological Process	GO:0019226	transmission of nerve impulse	IMP	J:155511
Biological Process	GO:0042060	wound healing	IBA	J:265628