GO Annotations Graph

• Symbol: Shmt2
• Name: serine hydroxymethyltransferase 2 (mitochondrial)
• ID: MGI:1277989

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016597	amino acid binding	ISO	J:155856
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	ISO	J:164563
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	ISO	J:155856
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	IBA	J:265628
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	IGI	J:150202
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	IMP	J:150202
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0008732	L-allo-threonine aldolase activity	ISO	J:155856
Molecular Function	GO:0048027	mRNA 5'-UTR binding	IBA	J:265628
Molecular Function	GO:0000900	mRNA regulatory element binding translation repressor activity	IBA	J:265628
Molecular Function	GO:0042803	protein homodimerization activity	IBA	J:265628
Molecular Function	GO:0030170	pyridoxal phosphate binding	ISO	J:155856
Molecular Function	GO:0030170	pyridoxal phosphate binding	ISO	J:164563
Molecular Function	GO:0030170	pyridoxal phosphate binding	IBA	J:265628
Molecular Function	GO:0070905	serine binding	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0008270	zinc ion binding	IBA	J:265628
Cellular Component	GO:0070552	BRISC complex	ISO	J:164563
Cellular Component	GO:0070552	BRISC complex	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:164563
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0005743	mitochondrial inner membrane	IBA	J:265628
Cellular Component	GO:0005743	mitochondrial inner membrane	HDA	J:100953
Cellular Component	GO:0005758	mitochondrial intermembrane space	ISO	J:155856
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:155856
Cellular Component	GO:0005759	mitochondrial matrix	IBA	J:265628
Cellular Component	GO:0042645	mitochondrial nucleoid	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IGI	J:150202
Cellular Component	GO:0005634	nucleus	IDA	J:150202
Cellular Component	GO:0005634	nucleus	IDA	J:150202
Biological Process	GO:0046655	folic acid metabolic process	IBA	J:265628
Biological Process	GO:0006545	glycine biosynthetic process	ISO	J:155856
Biological Process	GO:0019264	glycine biosynthetic process from serine	ISO	J:155856
Biological Process	GO:0019264	glycine biosynthetic process from serine	IBA	J:265628
Biological Process	GO:0006544	glycine metabolic process	ISO	J:164563
Biological Process	GO:0006544	glycine metabolic process	ISO	J:155856
Biological Process	GO:0006544	glycine metabolic process	ISO	J:164563
Biological Process	GO:0006564	L-serine biosynthetic process	ISO	J:155856
Biological Process	GO:0006565	L-serine catabolic process	IBA	J:265628
Biological Process	GO:0006563	L-serine metabolic process	ISO	J:164563
Biological Process	GO:0006730	one-carbon metabolic process	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0051289	protein homotetramerization	ISO	J:164563
Biological Process	GO:0051289	protein homotetramerization	IBA	J:265628
Biological Process	GO:0070536	protein K63-linked deubiquitination	ISO	J:164563
Biological Process	GO:0051262	protein tetramerization	ISO	J:164563
Biological Process	GO:0009113	purine nucleobase biosynthetic process	IBA	J:265628
Biological Process	GO:1903715	regulation of aerobic respiration	ISO	J:164563
Biological Process	GO:1903715	regulation of aerobic respiration	IMP	J:259713
Biological Process	GO:0070129	regulation of mitochondrial translation	IMP	J:259137
Biological Process	GO:0070129	regulation of mitochondrial translation	ISO	J:164563
Biological Process	GO:0070129	regulation of mitochondrial translation	IMP	J:259713
Biological Process	GO:0002082	regulation of oxidative phosphorylation	ISO	J:164563
Biological Process	GO:0002082	regulation of oxidative phosphorylation	IMP	J:259713
Biological Process	GO:0002082	regulation of oxidative phosphorylation	IBA	J:265628
Biological Process	GO:0034340	response to type I interferon	ISO	J:164563
Biological Process	GO:0034340	response to type I interferon	IBA	J:265628
Biological Process	GO:0035999	tetrahydrofolate interconversion	IBA	J:265628
Biological Process	GO:0035999	tetrahydrofolate interconversion	IMP	J:150202
Biological Process	GO:0046653	tetrahydrofolate metabolic process	ISO	J:164563