Lrp5 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Lrp5
low density lipoprotein receptor-related protein 5
MGI:1278315

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015026	coreceptor activity	IBA	J:265628
Molecular Function	GO:0071936	coreceptor activity involved in Wnt signaling pathway	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:145745
Molecular Function	GO:0005515	protein binding	IPI	J:141207
Molecular Function	GO:0005515	protein binding	IPI	J:145745
Molecular Function	GO:0042813	Wnt receptor activity	ISO	J:164563
Molecular Function	GO:0042813	Wnt receptor activity	IBA	J:265628
Molecular Function	GO:0042813	Wnt receptor activity	IDA	J:75973
Molecular Function	GO:0017147	Wnt-protein binding	ISO	J:164563
Molecular Function	GO:0017147	Wnt-protein binding	IBA	J:265628
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:75973
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:75973
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Biological Process	GO:0060612	adipose tissue development	IBA	J:265628
Biological Process	GO:0006865	amino acid transport	IMP	J:224066
Biological Process	GO:0060033	anatomical structure regression	IMP	J:101493
Biological Process	GO:0009952	anterior/posterior pattern specification	IBA	J:265628
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:91055
Biological Process	GO:1902262	apoptotic process involved in blood vessel morphogenesis	IMP	J:101493
Biological Process	GO:1902262	apoptotic process involved in blood vessel morphogenesis	IMP	J:101493
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:224066
Biological Process	GO:0060348	bone development	IMP	J:164779
Biological Process	GO:0048539	bone marrow development	IBA	J:265628
Biological Process	GO:0060349	bone morphogenesis	IBA	J:265628
Biological Process	GO:0046849	bone remodeling	IBA	J:265628
Biological Process	GO:0046849	bone remodeling	IMP	J:75973
Biological Process	GO:0046849	bone remodeling	IGI	J:146078
Biological Process	GO:0046849	bone remodeling	IMP	J:128871
Biological Process	GO:0046849	bone remodeling	IMP	J:111467
Biological Process	GO:0046849	bone remodeling	IGI	J:111359
Biological Process	GO:0046849	bone remodeling	IMP	J:133196
Biological Process	GO:0046849	bone remodeling	IMP	J:126821
Biological Process	GO:0046849	bone remodeling	IGI	J:146078
Biological Process	GO:0046849	bone remodeling	IMP	J:116515
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	IBA	J:265628
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	IMP	J:115934
Biological Process	GO:0060070	canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:99178
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:99178
Biological Process	GO:0060070	canonical Wnt signaling pathway	IDA	J:91019
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:99178
Biological Process	GO:0060070	canonical Wnt signaling pathway	IDA	J:75973
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:115934
Biological Process	GO:0042074	cell migration involved in gastrulation	IGI	J:91055
Biological Process	GO:0098609	cell-cell adhesion	IMP	J:224066
Biological Process	GO:0060764	cell-cell signaling involved in mammary gland development	IMP	J:115934
Biological Process	GO:0042632	cholesterol homeostasis	IBA	J:265628
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:81174
Biological Process	GO:0042733	embryonic digit morphogenesis	IGI	J:91055
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0060856	establishment of blood-brain barrier	IMP	J:215763
Biological Process	GO:1990963	establishment of blood-retinal barrier	IMP	J:215763
Biological Process	GO:0035426	extracellular matrix-cell signaling	IDA	J:107732
Biological Process	GO:0001702	gastrulation with mouth forming second	IBA	J:265628
Biological Process	GO:0001702	gastrulation with mouth forming second	IGI	J:91055
Biological Process	GO:0010467	gene expression	IMP	J:224066
Biological Process	GO:0035108	limb morphogenesis	IGI	J:111359
Biological Process	GO:0060603	mammary gland duct morphogenesis	IGI	J:150203
Biological Process	GO:0008078	mesodermal cell migration	IGI	J:91055
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0110135	Norrin signaling pathway	IDA	J:107732
Biological Process	GO:0002076	osteoblast development	IMP	J:164779
Biological Process	GO:0002076	osteoblast development	IBA	J:265628
Biological Process	GO:0002076	osteoblast development	IMP	J:116515
Biological Process	GO:0033687	osteoblast proliferation	IMP	J:75973
Biological Process	GO:0033687	osteoblast proliferation	IMP	J:75973
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IDA	J:107732
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:107732
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IMP	J:262349
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	IMP	J:75973
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:75973
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	IBA	J:265628
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:81174
Biological Process	GO:0061298	retina vasculature development in camera-type eye	IMP	J:215763
Biological Process	GO:0061298	retina vasculature development in camera-type eye	IMP	J:224066
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	ISO	J:155856
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	IGI	J:154020
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	IMP	J:135279
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	IMP	J:75973
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	IMP	J:135279
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	IGI	J:154020
Biological Process	GO:0061304	retinal blood vessel morphogenesis	IMP	J:249149
Biological Process	GO:0061304	retinal blood vessel morphogenesis	IBA	J:265628
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:152469
Biological Process	GO:0001944	vasculature development	IMP	J:101493
Biological Process	GO:0001944	vasculature development	IMP	J:101493
Biological Process	GO:0016055	Wnt signaling pathway	IMP	J:224066

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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