GO Annotations Graph

• Symbol: Hcn4
• Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
• ID: MGI:1298209

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030552	cAMP binding	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005222	intracellular cAMP-activated cation channel activity	ISO	J:164563
Molecular Function	GO:0005222	intracellular cAMP-activated cation channel activity	IMP	J:86988
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005267	potassium channel activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:96808
Molecular Function	GO:0005515	protein binding	IPI	J:144069
Molecular Function	GO:0005272	sodium channel activity	IEA	J:60000
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Molecular Function	GO:0005249	voltage-gated potassium channel activity	ISO	J:164563
Molecular Function	GO:0005249	voltage-gated potassium channel activity	IBA	J:265628
Molecular Function	GO:0086041	voltage-gated potassium channel activity involved in SA node cell action potential depolarization	ISO	J:164563
Molecular Function	GO:0005248	voltage-gated sodium channel activity	ISO	J:164563
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0030424	axon	IDA	J:189955
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0098855	HCN channel complex	ISO	J:164563
Cellular Component	GO:0098855	HCN channel complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Biological Process	GO:0071320	cellular response to cAMP	ISO	J:164563
Biological Process	GO:0071321	cellular response to cGMP	ISO	J:164563
Biological Process	GO:0001701	in utero embryonic development	IMP	J:86988
Biological Process	GO:0086046	membrane depolarization during SA node cell action potential	ISO	J:164563
Biological Process	GO:0006812	monoatomic cation transport	ISO	J:164563
Biological Process	GO:0006812	monoatomic cation transport	IMP	J:86988
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:1990573	potassium ion import across plasma membrane	ISO	J:164563
Biological Process	GO:0071805	potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0071805	potassium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006813	potassium ion transport	IEA	J:72247
Biological Process	GO:0006813	potassium ion transport	IEA	J:60000
Biological Process	GO:0098909	regulation of cardiac muscle cell action potential involved in regulation of contraction	ISO	J:164563
Biological Process	GO:0055117	regulation of cardiac muscle contraction	ISO	J:164563
Biological Process	GO:2001257	regulation of cation channel activity	NAS	J:320085
Biological Process	GO:0008016	regulation of heart contraction	IMP	J:86988
Biological Process	GO:0002027	regulation of heart rate	ISO	J:164563
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ISO	J:164563
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	NAS	J:320085
Biological Process	GO:0003254	regulation of membrane depolarization	ISO	J:164563
Biological Process	GO:0003254	regulation of membrane depolarization	IBA	J:265628
Biological Process	GO:0042391	regulation of membrane potential	ISO	J:164563
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0098907	regulation of SA node cell action potential	NAS	J:320085
Biological Process	GO:0086015	SA node cell action potential	ISO	J:164563
Biological Process	GO:0098719	sodium ion import across plasma membrane	ISO	J:164563
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006814	sodium ion transport	IEA	J:60000
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247