GO Annotations Graph

• Symbol: Itgb1bp1
• Name: integrin beta 1 binding protein 1
• ID: MGI:1306802

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005092	GDP-dissociation inhibitor activity	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0005178	integrin binding	ISO	J:73065
Molecular Function	GO:0019900	kinase binding	IPI	J:196103
Molecular Function	GO:0005515	protein binding	IPI	J:196108
Molecular Function	GO:0005515	protein binding	ISO	J:73065
Molecular Function	GO:0019901	protein kinase binding	IDA	J:196108
Cellular Component	GO:0071944	cell periphery	ISO	J:164563
Cellular Component	GO:0071944	cell periphery	IBA	J:265628
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0034451	centriolar satellite	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IDA	J:196108
Cellular Component	GO:0005856	cytoskeleton	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	IDA	J:196108
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:196108
Cellular Component	GO:0001726	ruffle	IDA	J:196108
Cellular Component	GO:0001726	ruffle	ISO	J:164563
Cellular Component	GO:0001726	ruffle	IBA	J:265628
Biological Process	GO:0032148	activation of protein kinase B activity	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0031214	biomineral tissue development	IEA	J:60000
Biological Process	GO:0097746	blood vessel diameter maintenance	ISO	J:164563
Biological Process	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	ISO	J:164563
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0033622	integrin activation	ISO	J:164563
Biological Process	GO:0033622	integrin activation	IDA	J:196096
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0051451	myoblast migration	IMP	J:196103
Biological Process	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration	IDA	J:196096
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010764	negative regulation of fibroblast migration	IDA	J:196096
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	IMP	J:196096
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	IBA	J:265628
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:0006469	negative regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0090315	negative regulation of protein targeting to membrane	ISO	J:164563
Biological Process	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	IDA	J:196096
Biological Process	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	IBA	J:265628
Biological Process	GO:0007219	Notch signaling pathway	IEA	J:60000
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	IDA	J:196103
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	IDA	J:196108
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	IDA	J:196103
Biological Process	GO:0051496	positive regulation of stress fiber assembly	IDA	J:196103
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0043113	receptor clustering	IDA	J:196096
Biological Process	GO:0030155	regulation of cell adhesion	ISO	J:73065
Biological Process	GO:0033628	regulation of cell adhesion mediated by integrin	IMP	J:196096
Biological Process	GO:0043087	regulation of GTPase activity	ISO	J:164563
Biological Process	GO:2001044	regulation of integrin-mediated signaling pathway	IDA	J:196103
Biological Process	GO:2001044	regulation of integrin-mediated signaling pathway	IMP	J:196096
Biological Process	GO:0035148	tube formation	ISO	J:164563