GO Annotations Graph

• Symbol: Tff2
• Name: trefoil factor 2 (spasmolytic protein 1)
• ID: MGI:1306805

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031723	CXCR4 chemokine receptor binding	IBA	J:265628
Molecular Function	GO:0031723	CXCR4 chemokine receptor binding	IDA	J:147597
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:147597
Cellular Component	GO:0005615	extracellular space	IDA	J:159596
Biological Process	GO:0019722	calcium-mediated signaling	IDA	J:147597
Biological Process	GO:0008283	cell population proliferation	IMP	J:74338
Biological Process	GO:0070098	chemokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0070098	chemokine-mediated signaling pathway	IGI	J:147597
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:74338
Biological Process	GO:0001696	gastric acid secretion	IMP	J:74338
Biological Process	GO:0001696	gastric acid secretion	IMP	J:74338
Biological Process	GO:0042116	macrophage activation	IMP	J:116628
Biological Process	GO:0030277	maintenance of gastrointestinal epithelium	IBA	J:265628
Biological Process	GO:0060455	negative regulation of gastric acid secretion	IBA	J:265628
Biological Process	GO:0060455	negative regulation of gastric acid secretion	IMP	J:74338
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:127260
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:116628
Biological Process	GO:0043031	negative regulation of macrophage activation	IMP	J:116628
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:74338
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:147597
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IGI	J:147597
Biological Process	GO:0030334	regulation of cell migration	IGI	J:147597