GO Annotations Graph

• Symbol: Cask
• Name: calcium/calmodulin dependent serine protein kinase
• ID: MGI:1309489

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005516	calmodulin binding	IEA	J:60000
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0042043	neurexin family protein binding	ISO	J:155856
Molecular Function	GO:0042043	neurexin family protein binding	IDA	J:169741
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:169741
Molecular Function	GO:0005515	protein binding	IPI	J:169741
Molecular Function	GO:0005515	protein binding	IPI	J:169741
Molecular Function	GO:0005515	protein binding	IPI	J:77463
Molecular Function	GO:0005515	protein binding	IPI	J:222552
Molecular Function	GO:0005515	protein binding	IPI	J:78720
Molecular Function	GO:0005515	protein binding	IPI	J:169741
Molecular Function	GO:0005515	protein binding	IPI	J:169741
Molecular Function	GO:0005515	protein binding	IPI	J:80555
Molecular Function	GO:0005515	protein binding	IPI	J:147029
Molecular Function	GO:0005515	protein binding	IPI	J:102649
Molecular Function	GO:0005515	protein binding	IPI	J:169741
Molecular Function	GO:0005515	protein binding	IPI	J:114313
Molecular Function	GO:0005515	protein binding	IPI	J:201692
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0097440	apical dendrite	ISO	J:155856
Cellular Component	GO:0005604	basement membrane	IDA	J:139951
Cellular Component	GO:0005604	basement membrane	ISO	J:164563
Cellular Component	GO:0005604	basement membrane	ISO	J:164563
Cellular Component	GO:0005604	basement membrane	IDA	J:139951
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	IBA	J:265628
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:114313
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:80555
Cellular Component	GO:0005911	cell-cell junction	IDA	J:139951
Cellular Component	GO:0005911	cell-cell junction	IDA	J:139951
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IBA	J:265628
Cellular Component	GO:0060170	ciliary membrane	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:139951
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:139951
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9610428
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9610641
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9659536
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9663360
Cellular Component	GO:0005829	cytosol	IDA	J:78720
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:169741
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005652	nuclear lamina	ISO	J:164563
Cellular Component	GO:0016363	nuclear matrix	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:139951
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:139951
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0098846	podocyte foot	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:117978
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:117978
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:117978
Cellular Component	GO:0045202	synapse	IDA	J:78720
Cellular Component	GO:0045202	synapse	IDA	J:102649
Cellular Component	GO:0045202	synapse	IDA	J:86623
Cellular Component	GO:0045202	synapse	IDA	J:169741
Cellular Component	GO:0097060	synaptic membrane	ISO	J:155856
Cellular Component	GO:0031982	vesicle	IDA	J:142497
Biological Process	GO:0070509	calcium ion import	IMP	J:169741
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:169741
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0090288	negative regulation of cellular response to growth factor stimulus	ISO	J:164563
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	ISO	J:164563
Biological Process	GO:0061045	negative regulation of wound healing	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0090280	positive regulation of calcium ion import	IDA	J:169741
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	ISO	J:155856
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:94801
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0046928	regulation of neurotransmitter secretion	IBA	J:265628
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	IDA	J:117978
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	IMP	J:117978
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	IDA	J:117978
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:155856