GO Annotations Graph

• Symbol: Casp12
• Name: caspase 12
• ID: MGI:1312922

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:220516
Molecular Function	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	IBA	J:265628
Molecular Function	GO:0008234	cysteine-type peptidase activity	ISO	J:155856
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	RCA	J:84168
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:186075
Molecular Function	GO:0005515	protein binding	IPI	J:87334
Molecular Function	GO:0005515	protein binding	IPI	J:87334
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:59337
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	TAS	J:87334
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:62257
Biological Process	GO:0044346	fibroblast apoptotic process	IDA	J:84272
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:59337
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	TAS	J:180458
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA	J:220516
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IGI	J:84272
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IGI	J:84272
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0010663	positive regulation of striated muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0016540	protein autoprocessing	ISO	J:155856
Biological Process	GO:0030163	protein catabolic process	ISO	J:155856
Biological Process	GO:0006508	proteolysis	RCA	J:84168
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0097264	self proteolysis	IDA	J:220516