GO Annotations Graph

• Symbol: Vamp2
• Name: vesicle-associated membrane protein 2
• ID: MGI:1313277

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	IDA	J:78421
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0008289	lipid binding	ISO	J:155856
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:155856
Molecular Function	GO:0017022	myosin binding	ISO	J:155856
Molecular Function	GO:0005543	phospholipid binding	IDA	J:78421
Molecular Function	GO:0005515	protein binding	IPI	J:266473
Molecular Function	GO:0005515	protein binding	IPI	J:218865
Molecular Function	GO:0005515	protein binding	IPI	J:119733
Molecular Function	GO:0005515	protein binding	IPI	J:157635
Molecular Function	GO:0005515	protein binding	IPI	J:159065
Molecular Function	GO:0005515	protein binding	IPI	J:245395
Molecular Function	GO:0005515	protein binding	IPI	J:273533
Molecular Function	GO:0005515	protein binding	IPI	J:140958
Molecular Function	GO:0005515	protein binding	IPI	J:248215
Molecular Function	GO:0005515	protein binding	IPI	J:181971
Molecular Function	GO:0005515	protein binding	IPI	J:157584
Molecular Function	GO:0005515	protein binding	IPI	J:200387
Molecular Function	GO:0005515	protein binding	IPI	J:225407
Molecular Function	GO:0005515	protein binding	IPI	J:164218
Molecular Function	GO:0005515	protein binding	IPI	J:167753
Molecular Function	GO:0005515	protein binding	IPI	J:55848
Molecular Function	GO:0005515	protein binding	IPI	J:140969
Molecular Function	GO:0005515	protein binding	IPI	J:151132
Molecular Function	GO:0005515	protein binding	IPI	J:167753
Molecular Function	GO:0005515	protein binding	IPI	J:167753
Molecular Function	GO:0005515	protein binding	IPI	J:139769
Molecular Function	GO:0005515	protein binding	IPI	J:167753
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0005484	SNAP receptor activity	IBA	J:265628
Molecular Function	GO:0000149	SNARE binding	ISO	J:155856
Molecular Function	GO:0000149	SNARE binding	IDA	J:78421
Molecular Function	GO:0000149	SNARE binding	ISO	J:29256
Molecular Function	GO:0019905	syntaxin binding	ISO	J:164563
Molecular Function	GO:0019905	syntaxin binding	IPI	J:161112
Molecular Function	GO:0017075	syntaxin-1 binding	IDA	J:138035
Molecular Function	GO:0017075	syntaxin-1 binding	ISO	J:155856
Molecular Function	GO:0017075	syntaxin-1 binding	IBA	J:265628
Molecular Function	GO:0017075	syntaxin-1 binding	ISO	J:29256
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Cellular Component	GO:0030136	clathrin-coated vesicle	ISO	J:164563
Cellular Component	GO:0060203	clathrin-sculpted glutamate transport vesicle membrane	TAS	Reactome:R-MMU-9664156
Cellular Component	GO:0005737	cytoplasm	IDA	J:273533
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:139769
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	TAS	Reactome:R-MMU-1449573
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	IDA	J:80816
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0043229	intracellular organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:197701
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0044306	neuron projection terminus	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:140958
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:139769
Cellular Component	GO:0005886	plasma membrane	IDA	J:182176
Cellular Component	GO:0030141	secretory granule	IDA	J:273533
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	IDA	J:78421
Cellular Component	GO:0030667	secretory granule membrane	TAS	Reactome:R-MMU-216883
Cellular Component	GO:0031201	SNARE complex	ISO	J:164563
Cellular Component	GO:0031201	SNARE complex	ISO	J:155856
Cellular Component	GO:0031201	SNARE complex	IBA	J:265628
Cellular Component	GO:0031201	SNARE complex	IDA	J:137704
Cellular Component	GO:0000322	storage vacuole	IDA	J:182176
Cellular Component	GO:0045202	synapse	IDA	J:140969
Cellular Component	GO:0045202	synapse	IDA	J:167591
Cellular Component	GO:0045202	synapse	IDA	J:140969
Cellular Component	GO:0045202	synapse	IDA	J:213593
Cellular Component	GO:0045202	synapse	IDA	J:140969
Cellular Component	GO:0045202	synapse	IDA	J:201692
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	IDA	J:91381
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0030672	synaptic vesicle membrane	IDA	J:84542
Cellular Component	GO:0030672	synaptic vesicle membrane	IDA	J:90137
Cellular Component	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex	ISO	J:155856
Cellular Component	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex	ISO	J:29256
Cellular Component	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex	IDA	J:167753
Cellular Component	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	ISO	J:29256
Cellular Component	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex	ISO	J:155856
Cellular Component	GO:0005802	trans-Golgi network	IDA	J:140958
Cellular Component	GO:0031982	vesicle	ISO	J:164563
Cellular Component	GO:0031982	vesicle	IDA	J:225407
Cellular Component	GO:0042589	zymogen granule membrane	IDA	J:84542
Biological Process	GO:0017156	calcium-ion regulated exocytosis	IMP	J:100913
Biological Process	GO:0017156	calcium-ion regulated exocytosis	IDA	J:78421
Biological Process	GO:0032869	cellular response to insulin stimulus	IDA	J:131844
Biological Process	GO:0043308	eosinophil degranulation	ISO	J:164563
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:100913
Biological Process	GO:0098967	exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IMP	J:197846
Biological Process	GO:0098967	exocytic insertion of neurotransmitter receptor to postsynaptic membrane	ISO	J:155856
Biological Process	GO:0043001	Golgi to plasma membrane protein transport	IMP	J:165162
Biological Process	GO:0046879	hormone secretion	IDA	J:273533
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:197846
Biological Process	GO:0061025	membrane fusion	IMP	J:100913
Biological Process	GO:0090316	positive regulation of intracellular protein transport	IMP	J:131844
Biological Process	GO:0015031	protein transport	ISO	J:155856
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:155856
Biological Process	GO:0045055	regulated exocytosis	IDA	J:273533
Biological Process	GO:0017158	regulation of calcium ion-dependent exocytosis	TAS	J:212808
Biological Process	GO:1902259	regulation of delayed rectifier potassium channel activity	ISO	J:155856
Biological Process	GO:0017157	regulation of exocytosis	ISO	J:155856
Biological Process	GO:0017157	regulation of exocytosis	IDA	J:78421
Biological Process	GO:1903421	regulation of synaptic vesicle recycling	ISO	J:155856
Biological Process	GO:0060627	regulation of vesicle-mediated transport	IMP	J:131844
Biological Process	GO:0009749	response to glucose	ISO	J:155856
Biological Process	GO:0035493	SNARE complex assembly	ISO	J:155856
Biological Process	GO:0035493	SNARE complex assembly	IBA	J:265628
Biological Process	GO:0016081	synaptic vesicle docking	IDA	J:218225
Biological Process	GO:0016081	synaptic vesicle docking	IMP	J:218225
Biological Process	GO:0016081	synaptic vesicle docking	IDA	J:218225
Biological Process	GO:0016081	synaptic vesicle docking	IDA	J:218225
Biological Process	GO:0048488	synaptic vesicle endocytosis	IMP	J:96873
Biological Process	GO:0016079	synaptic vesicle exocytosis	ISO	J:155856
Biological Process	GO:0016079	synaptic vesicle exocytosis	IMP	J:96873
Biological Process	GO:0016079	synaptic vesicle exocytosis	IMP	J:72714
Biological Process	GO:0006906	vesicle fusion	ISO	J:164563
Biological Process	GO:0006906	vesicle fusion	IBA	J:265628
Biological Process	GO:0016192	vesicle-mediated transport	ISO	J:155856