GO Annotations Graph

• Symbol: Cldn4
• Name: claudin 4
• ID: MGI:1313314

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005254	chloride channel activity	IMP	J:165532
Molecular Function	GO:0005515	protein binding	IPI	J:58914
Molecular Function	GO:0005515	protein binding	IPI	J:165532
Molecular Function	GO:0005198	structural molecule activity	IEA	J:72247
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016327	apicolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0016327	apicolateral plasma membrane	IDA	J:61744
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:155856
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:198884
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:165532
Cellular Component	GO:0005923	bicellular tight junction	ISO	J:164563
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:61744
Cellular Component	GO:0005923	bicellular tight junction	IBA	J:265628
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:97223
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:107229
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:197681
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0034707	chloride channel complex	IEA	J:60000
Cellular Component	GO:0016328	lateral plasma membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	NAS	J:61744
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:97223
Cellular Component	GO:0070160	tight junction	IDA	J:280385
Cellular Component	GO:0070160	tight junction	ISO	J:164563
Biological Process	GO:0070830	bicellular tight junction assembly	IBA	J:265628
Biological Process	GO:0007155	cell adhesion	IBA	J:265628
Biological Process	GO:0006821	chloride transport	IEA	J:60000
Biological Process	GO:0061436	establishment of skin barrier	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:1905050	positive regulation of metallopeptidase activity	ISO	J:164563
Biological Process	GO:0090303	positive regulation of wound healing	ISO	J:164563
Biological Process	GO:0022604	regulation of cell morphogenesis	ISO	J:164563
Biological Process	GO:0070293	renal absorption	IMP	J:165532