GO Annotations Graph

• Symbol: Afdn
• Name: afadin, adherens junction formation factor
• ID: MGI:1314653

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0050839	cell adhesion molecule binding	IPI	J:143697
Molecular Function	GO:0050839	cell adhesion molecule binding	IBA	J:265628
Molecular Function	GO:0030274	LIM domain binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:180687
Molecular Function	GO:0005515	protein binding	IPI	J:81692
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Cellular Component	GO:0005912	adherens junction	ISO	J:155856
Cellular Component	GO:0005912	adherens junction	IBA	J:265628
Cellular Component	GO:0005912	adherens junction	IDA	J:78857
Cellular Component	GO:0005912	adherens junction	IDA	J:82002
Cellular Component	GO:0005912	adherens junction	IDA	J:73293
Cellular Component	GO:0005912	adherens junction	IDA	J:101707
Cellular Component	GO:0005912	adherens junction	IDA	J:73293
Cellular Component	GO:0043296	apical junction complex	IDA	J:213985
Cellular Component	GO:0045177	apical part of cell	IDA	J:61349
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IDA	J:93218
Cellular Component	GO:0044291	cell-cell contact zone	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IDA	J:204548
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IDA	J:145651
Cellular Component	GO:0005737	cytoplasm	IDA	J:180687
Cellular Component	GO:0005737	cytoplasm	IDA	J:93218
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0060076	excitatory synapse	ISO	J:155856
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0046930	pore complex	ISO	J:164563
Cellular Component	GO:0046930	pore complex	IMP	J:276415
Cellular Component	GO:0036477	somatodendritic compartment	ISO	J:155856
Cellular Component	GO:0070160	tight junction	ISO	J:164563
Biological Process	GO:0034334	adherens junction maintenance	IMP	J:215584
Biological Process	GO:0070830	bicellular tight junction assembly	ISO	J:164563
Biological Process	GO:0048854	brain morphogenesis	IGI	J:215584
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0044331	cell-cell adhesion mediated by cadherin	IMP	J:204548
Biological Process	GO:0021987	cerebral cortex development	IMP	J:215584
Biological Process	GO:0021987	cerebral cortex development	IGI	J:215584
Biological Process	GO:0140059	dendrite arborization	ISO	J:155856
Biological Process	GO:0090557	establishment of endothelial intestinal barrier	ISO	J:164563
Biological Process	GO:0061951	establishment of protein localization to plasma membrane	IMP	J:204548
Biological Process	GO:0061951	establishment of protein localization to plasma membrane	IMP	J:204548
Biological Process	GO:0061951	establishment of protein localization to plasma membrane	IMP	J:204548
Biological Process	GO:0048872	homeostasis of number of cells	IGI	J:215584
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0060563	neuroepithelial cell differentiation	IGI	J:215584
Biological Process	GO:0046931	pore complex assembly	IMP	J:276415
Biological Process	GO:0046931	pore complex assembly	ISO	J:164563
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	ISO	J:164563
Biological Process	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	ISO	J:164563
Biological Process	GO:1903861	positive regulation of dendrite extension	ISO	J:155856
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	ISO	J:155856
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0061885	positive regulation of mini excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:1902414	protein localization to cell junction	IMP	J:213985
Biological Process	GO:0060019	radial glial cell differentiation	IGI	J:215584
Biological Process	GO:0070445	regulation of oligodendrocyte progenitor proliferation	IGI	J:215584
Biological Process	GO:0032880	regulation of protein localization	IBA	J:265628
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0021537	telencephalon development	IGI	J:215584