GO Annotations Graph

• Symbol: Hipk2
• Name: homeodomain interacting protein kinase 2
• ID: MGI:1314872

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:197686
Molecular Function	GO:0005515	protein binding	IPI	J:89440
Molecular Function	GO:0005515	protein binding	IPI	J:50387
Molecular Function	GO:0005515	protein binding	IPI	J:161258
Molecular Function	GO:0005515	protein binding	IPI	J:143816
Molecular Function	GO:0005515	protein binding	IPI	J:162445
Molecular Function	GO:0005515	protein binding	IPI	J:93311
Molecular Function	GO:0005515	protein binding	IPI	J:94782
Molecular Function	GO:0005515	protein binding	IPI	J:94782
Molecular Function	GO:0004672	protein kinase activity	IDA	J:50387
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:180474
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISA	J:65481
Molecular Function	GO:0004713	protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:180474
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	IBA	J:265628
Molecular Function	GO:0003713	transcription coactivator activity	IMP	J:180474
Molecular Function	GO:0003713	transcription coactivator activity	IBA	J:265628
Molecular Function	GO:0003714	transcription corepressor activity	ISO	J:164563
Molecular Function	GO:0003714	transcription corepressor activity	IDA	J:50387
Molecular Function	GO:0003714	transcription corepressor activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0046790	virion binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:65841
Cellular Component	GO:0010494	cytoplasmic stress granule	ISO	J:164563
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:162323
Cellular Component	GO:0005634	nucleus	IDA	J:50387
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0016605	PML body	ISO	J:164563
Cellular Component	GO:0016605	PML body	IBA	J:265628
Cellular Component	GO:0016605	PML body	TAS	J:81640
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IMP	J:180474
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:117465
Biological Process	GO:0007628	adult walking behavior	IMP	J:117465
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:106931
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:106931
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0008283	cell population proliferation	IGI	J:106931
Biological Process	GO:0008283	cell population proliferation	IGI	J:106931
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISO	J:164563
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	IMP	J:162323
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	IMP	J:162323
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA	J:265628
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI	J:106931
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI	J:106931
Biological Process	GO:0061072	iris morphogenesis	IMP	J:162323
Biological Process	GO:0060235	lens induction in camera-type eye	IMP	J:162323
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:117465
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:50387
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:117465
Biological Process	GO:0030182	neuron differentiation	IMP	J:162323
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:180474
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IDA	J:180474
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:106931
Biological Process	GO:0043388	positive regulation of DNA binding	IDA	J:50387
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IDA	J:180474
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0032092	positive regulation of protein binding	IDA	J:180474
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IGI	J:162445
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:180474
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:50387
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IGI	J:162445
Biological Process	GO:0010842	retina layer formation	IMP	J:162323
Biological Process	GO:0060395	SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0007224	smoothened signaling pathway	IBA	J:265628
Biological Process	GO:0007224	smoothened signaling pathway	IGI	J:106931
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:117465
Biological Process	GO:0050882	voluntary musculoskeletal movement	IMP	J:117465