GO Annotations Graph

• Symbol: Tnfrsf1a
• Name: tumor necrosis factor receptor superfamily, member 1a
• ID: MGI:1314884

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:201253
Molecular Function	GO:0005515	protein binding	IPI	J:228302
Molecular Function	GO:0005515	protein binding	IPI	J:164288
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:218005
Molecular Function	GO:0005515	protein binding	IPI	J:200442
Molecular Function	GO:0005515	protein binding	IPI	J:138824
Molecular Function	GO:0005515	protein binding	IPI	J:128397
Molecular Function	GO:0005515	protein binding	IPI	J:128397
Molecular Function	GO:0005515	protein binding	IPI	J:151999
Molecular Function	GO:0005515	protein binding	IPI	J:128397
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0043120	tumor necrosis factor binding	ISO	J:164563
Molecular Function	GO:0043120	tumor necrosis factor binding	ISO	J:155856
Molecular Function	GO:0043120	tumor necrosis factor binding	IBA	J:265628
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	ISO	J:164563
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	ISO	J:155856
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	IBA	J:265628
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	IPI	J:11207
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	IPI	J:11207
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	TAS	J:52096
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	IMP	J:72219
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	TAS	J:45147
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:180537
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0000139	Golgi membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	IDA	J:143672
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	J:45147
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0003176	aortic valve development	IGI	J:261826
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0007166	cell surface receptor signaling pathway	IMP	J:45147
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IMP	J:72219
Biological Process	GO:0006952	defense response	IMP	J:4753
Biological Process	GO:0042742	defense response to bacterium	IMP	J:43155
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0006954	inflammatory response	IMP	J:45147
Biological Process	GO:0006954	inflammatory response	IMP	J:52096
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:121372
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0010614	negative regulation of cardiac muscle hypertrophy	IGI	J:261826
Biological Process	GO:0003332	negative regulation of extracellular matrix constituent secretion	IGI	J:261826
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:1902339	positive regulation of apoptotic process involved in morphogenesis	IGI	J:261826
Biological Process	GO:1902339	positive regulation of apoptotic process involved in morphogenesis	IGI	J:261826
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0050729	positive regulation of inflammatory response	IMP	J:72219
Biological Process	GO:0050729	positive regulation of inflammatory response	IMP	J:208995
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:72219
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0006693	prostaglandin metabolic process	TAS	J:4753
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0003177	pulmonary valve development	IGI	J:261826
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:155856
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	IGI	J:277582
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:72219
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	ISO	J:164563