GO Annotations Graph

• Symbol: Hk2
• Name: hexokinase 2
• ID: MGI:1315197

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0008865	fructokinase activity	ISO	J:155856
Molecular Function	GO:0008865	fructokinase activity	IBA	J:265628
Molecular Function	GO:0004340	glucokinase activity	ISO	J:164563
Molecular Function	GO:0004340	glucokinase activity	ISO	J:155856
Molecular Function	GO:0004340	glucokinase activity	IBA	J:265628
Molecular Function	GO:0005536	glucose binding	ISO	J:155856
Molecular Function	GO:0004396	hexokinase activity	ISO	J:164563
Molecular Function	GO:0004396	hexokinase activity	ISO	J:155856
Molecular Function	GO:0004396	hexokinase activity	IDA	J:132397
Molecular Function	GO:0004396	hexokinase activity	IMP	J:56644
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA	J:72247
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:73065
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0016529	sarcoplasmic reticulum	ISO	J:155856
Biological Process	GO:0008637	apoptotic mitochondrial changes	IGI	J:133172
Biological Process	GO:0008637	apoptotic mitochondrial changes	ISO	J:73065
Biological Process	GO:0008637	apoptotic mitochondrial changes	IGI	J:133172
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:72247
Biological Process	GO:0046835	carbohydrate phosphorylation	ISO	J:155856
Biological Process	GO:0046835	carbohydrate phosphorylation	IBA	J:265628
Biological Process	GO:0046835	carbohydrate phosphorylation	IMP	J:56644
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0072655	establishment of protein localization to mitochondrion	ISO	J:164563
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	ISO	J:155856
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	ISO	J:164563
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	ISO	J:155856
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	IBA	J:265628
Biological Process	GO:0006006	glucose metabolic process	IBA	J:265628
Biological Process	GO:0006006	glucose metabolic process	IMP	J:56644
Biological Process	GO:0006096	glycolytic process	IBA	J:265628
Biological Process	GO:0001678	intracellular glucose homeostasis	IBA	J:265628
Biological Process	GO:0072656	maintenance of protein location in mitochondrion	ISO	J:164563
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0035795	negative regulation of mitochondrial membrane permeability	IMP	J:219066
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	IMP	J:219066
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	ISO	J:164563
Biological Process	GO:0046324	regulation of glucose import	IMP	J:126561
Biological Process	GO:0002931	response to ischemia	ISO	J:155856