Sphk1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Sphk1
sphingosine kinase 1
MGI:1316649

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016407	acetyltransferase activity	IMP	J:261928
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	ISO	J:80926
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	IDA	J:49744
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	ISO	J:164563
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	ISO	J:155856
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	IDA	J:271700
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	ISO	J:80926
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0016301	kinase activity	IEA	J:72247
Molecular Function	GO:0008289	lipid binding	ISO	J:164563
Molecular Function	GO:0001727	lipid kinase activity	IBA	J:265628
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0003951	NAD+ kinase activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0051721	protein phosphatase 2A binding	ISO	J:164563
Molecular Function	GO:0008481	sphinganine kinase activity	IDA	J:281260
Molecular Function	GO:0008481	sphinganine kinase activity	IDA	J:304931
Molecular Function	GO:0008481	sphinganine kinase activity	ISO	J:80926
Molecular Function	GO:0008481	sphinganine kinase activity	ISO	J:73065
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:273514
Cellular Component	GO:0005737	cytoplasm	IDA	J:261928
Cellular Component	GO:0005737	cytoplasm	IMP	J:240895
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0031901	early endosome membrane	ISO	J:164563
Cellular Component	GO:0030139	endocytic vesicle	IDA	J:240895
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IBA	J:265628
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:261928
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0098793	presynapse	IDA	J:219391
Cellular Component	GO:0045202	synapse	IEA	J:60000
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Biological Process	GO:0001568	blood vessel development	IGI	J:103755
Biological Process	GO:0007420	brain development	IGI	J:103755
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IGI	J:103755
Biological Process	GO:0071363	cellular response to growth factor stimulus	IBA	J:265628
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IDA	J:202378
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	IDA	J:281260
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0019371	cyclooxygenase pathway	ISO	J:155856
Biological Process	GO:0071897	DNA biosynthetic process	IMP	J:202378
Biological Process	GO:0006954	inflammatory response	IMP	J:133917
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:273514
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:73065
Biological Process	GO:1900060	negative regulation of ceramide biosynthetic process	ISO	J:164563
Biological Process	GO:1900060	negative regulation of ceramide biosynthetic process	IMP	J:273514
Biological Process	GO:0016310	phosphorylation	IDA	J:49744
Biological Process	GO:0016310	phosphorylation	IBA	J:265628
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:103755
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:73065
Biological Process	GO:0032740	positive regulation of interleukin-17 production	ISO	J:155856
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	IGI	J:202378
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0001956	positive regulation of neurotransmitter secretion	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:155856
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	ISO	J:164563
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	ISO	J:164563
Biological Process	GO:0006473	protein acetylation	IMP	J:261928
Biological Process	GO:0030100	regulation of endocytosis	IMP	J:273518
Biological Process	GO:0030100	regulation of endocytosis	IMP	J:240895
Biological Process	GO:0030100	regulation of endocytosis	ISO	J:164563
Biological Process	GO:1905364	regulation of endosomal vesicle fusion	IMP	J:240895
Biological Process	GO:0032651	regulation of interleukin-1 beta production	IMP	J:133917
Biological Process	GO:1903978	regulation of microglial cell activation	IMP	J:261928
Biological Process	GO:0150077	regulation of neuroinflammatory response	ISO	J:155856
Biological Process	GO:0150077	regulation of neuroinflammatory response	IMP	J:261928
Biological Process	GO:0050764	regulation of phagocytosis	IMP	J:261928
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0034612	response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0090520	sphingolipid mediated signaling pathway	IDA	J:202378
Biological Process	GO:0046512	sphingosine biosynthetic process	ISO	J:164563
Biological Process	GO:0046512	sphingosine biosynthetic process	IBA	J:265628
Biological Process	GO:0006670	sphingosine metabolic process	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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