GO Annotations Graph

• Symbol: Sphk1
• Name: sphingosine kinase 1
• ID: MGI:1316649

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016407	acetyltransferase activity	IMP	J:261928
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	ISO	J:80926
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	IDA	J:49744
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	ISO	J:164563
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	ISO	J:155856
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	IDA	J:271700
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	ISO	J:80926
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0016301	kinase activity	IEA	J:72247
Molecular Function	GO:0008289	lipid binding	ISO	J:164563
Molecular Function	GO:0001727	lipid kinase activity	IBA	J:265628
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0003951	NAD+ kinase activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0051721	protein phosphatase 2A binding	ISO	J:164563
Molecular Function	GO:0008481	sphinganine kinase activity	IDA	J:281260
Molecular Function	GO:0008481	sphinganine kinase activity	IDA	J:304931
Molecular Function	GO:0008481	sphinganine kinase activity	ISO	J:80926
Molecular Function	GO:0008481	sphinganine kinase activity	ISO	J:73065
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:273514
Cellular Component	GO:0005737	cytoplasm	IDA	J:261928
Cellular Component	GO:0005737	cytoplasm	IMP	J:240895
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0031901	early endosome membrane	ISO	J:164563
Cellular Component	GO:0030139	endocytic vesicle	IDA	J:240895
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IBA	J:265628
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:261928
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0098793	presynapse	IDA	J:219391
Cellular Component	GO:0045202	synapse	IEA	J:60000
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Biological Process	GO:0001568	blood vessel development	IGI	J:103755
Biological Process	GO:0007420	brain development	IGI	J:103755
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IGI	J:103755
Biological Process	GO:0071363	cellular response to growth factor stimulus	IBA	J:265628
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IDA	J:202378
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	IDA	J:281260
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0019371	cyclooxygenase pathway	ISO	J:155856
Biological Process	GO:0071897	DNA biosynthetic process	IMP	J:202378
Biological Process	GO:0006954	inflammatory response	IMP	J:133917
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:273514
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:73065
Biological Process	GO:1900060	negative regulation of ceramide biosynthetic process	ISO	J:164563
Biological Process	GO:1900060	negative regulation of ceramide biosynthetic process	IMP	J:273514
Biological Process	GO:0016310	phosphorylation	IDA	J:49744
Biological Process	GO:0016310	phosphorylation	IBA	J:265628
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:103755
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:73065
Biological Process	GO:0032740	positive regulation of interleukin-17 production	ISO	J:155856
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	IGI	J:202378
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0001956	positive regulation of neurotransmitter secretion	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:155856
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	ISO	J:164563
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	ISO	J:164563
Biological Process	GO:0006473	protein acetylation	IMP	J:261928
Biological Process	GO:0030100	regulation of endocytosis	IMP	J:273518
Biological Process	GO:0030100	regulation of endocytosis	IMP	J:240895
Biological Process	GO:0030100	regulation of endocytosis	ISO	J:164563
Biological Process	GO:1905364	regulation of endosomal vesicle fusion	IMP	J:240895
Biological Process	GO:0032651	regulation of interleukin-1 beta production	IMP	J:133917
Biological Process	GO:1903978	regulation of microglial cell activation	IMP	J:261928
Biological Process	GO:0150077	regulation of neuroinflammatory response	ISO	J:155856
Biological Process	GO:0150077	regulation of neuroinflammatory response	IMP	J:261928
Biological Process	GO:0050764	regulation of phagocytosis	IMP	J:261928
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0034612	response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0090520	sphingolipid mediated signaling pathway	IDA	J:202378
Biological Process	GO:0046512	sphingosine biosynthetic process	ISO	J:164563
Biological Process	GO:0046512	sphingosine biosynthetic process	IBA	J:265628
Biological Process	GO:0006670	sphingosine metabolic process	ISO	J:164563