GO Annotations Graph

• Symbol: Sh2d1a
• Name: SH2 domain containing 1A
• ID: MGI:1328352

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:111421
Molecular Function	GO:0005515	protein binding	IPI	J:145969
Molecular Function	GO:0005515	protein binding	IPI	J:64014
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0007267	cell-cell signaling	IEA	J:72247
Biological Process	GO:0006968	cellular defense response	IEA	J:72247
Biological Process	GO:0006959	humoral immune response	IMP	J:89595
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	IGI	J:151768
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	IMP	J:110195
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	IGI	J:151768
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IMP	J:110195
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IGI	J:151768
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IGI	J:151768
Biological Process	GO:0050776	regulation of immune response	ISO	J:164563